ReviewAnnual review of biomedical engineering2010
Microfluidic technologies for temporal perturbations of chemotaxis.
Review in Annual review of biomedical engineering, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 61 citations in OpenAlex.
- Engineering global and local signal generators for probing temporal and spatial cellular signaling dynamics.Frontiers in bioengineering and biotechnology · 2023Review
- Signal integration in forward and reverse neutrophil migration: Fundamentals and emerging mechanisms.Current opinion in cell biology · 2021Review
- Analysis of barotactic and chemotactic guidance cues on directional decision-making ofProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Genetic manipulation of PLB-985 cells and quantification of chemotaxis using the underagarose assay.Methods in cell biology · 2019Article
- A sharp-edge-based acoustofluidic chemical signal generator.Lab on a chip · 2018Article
- Probing the Bi-directional Interaction Between Microglia and Gliomas in a Tumor Microenvironment on a Microdevice.Neurochemical research · 2017Article
- Simultaneous or Sequential Orthogonal Gradient Formation in a 3D Cell Culture Microfluidic Platform.Small (Weinheim an der Bergstrasse, Germany) · 2016Article
- EGF as a New Therapeutic Target for Medulloblastoma Metastasis.Cellular and molecular bioengineering · 2015Article
- A spatiotemporally controllable chemical gradient generator via acoustically oscillating sharp-edge structures.Lab on a chip · 2015Article
- A neutrophil treadmill to decouple spatial and temporal signals during chemotaxis.Lab on a chip · 2015Article
- Rectified directional sensing in long-range cell migration.Nature communications · 2014Article
- Collective and individual migration following the epithelial-mesenchymal transition.Nature materials · 2014Article
- Gradient generation platforms: new directions for an established microfluidic technology.Lab on a chip · 2014Article
- A microfluidic-based genetic screen to identify microbial virulence factors that inhibit dendritic cell migration.Integrative biology : quantitative biosciences from nano to macro · 2014Article
- Review
- On-demand, competing gradient arrays for neutrophil chemotaxis.Lab on a chip · 2014Article
- Article
- Resolvin D2 restores neutrophil directionality and improves survival after burns.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Convolution of chemoattractant secretion rate, source density, and receptor desensitization direct diverse migration patterns in leukocytes.Integrative biology : quantitative biosciences from nano to macro · 2013Article
- Tunable, pulsatile chemical gradient generation via acoustically driven oscillating bubbles.Lab on a chip · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Most cells in the body have the ability to change their physical locations during physiologic or pathologic events such as inflammation, wound healing, or cancer. When cell migration is directed toward sources of cue chemicals, the process is known as chemotaxis, and it requires linking the sensing of chemicals through receptors on the surfaces of the cells to the directional activation of the motility apparatus inside the cells. This link is supported by complex intracellular signaling pathways, and although details regarding the nature of the molecules involved in the signal transduction are well established, far less is known about how different signaling molecules and processes are dynamically interconnected and how slower and faster signaling events take place simultaneously inside moving cells. In this context, advances in microfluidic technologies are enabling the emergence of new tools that facilitate the development of experimental protocols in which the cellular microenvironment is precisely controlled in time and space and in which signaling-associated changes inside cells can be quantitatively measured and compared. These tools could enable new insights into the intricacies of the biological systems that participate in chemotaxis processes and could have the potential to accelerate the development of novel therapeutic strategies to control cell motility and enhance our abilities for medical intervention during health and disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.