SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2010
A systematic review of oral fungal infections in patients receiving cancer therapy.
Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
105 citing papers in PubMed, 3 syntheses or guidelines pooled it, 262 citations in OpenAlex.
- MASCC/ISOO expert opinion on the management of oral problems in patients with advanced cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Guideline
- Candidiasis (oropharyngeal).BMJ clinical evidence · 2013Pooled it
- Candidiasis (oropharyngeal).BMJ clinical evidence · 2012Pooled it
- The effects of a combination oral spray (Mucosamin®) for the prevention of oral mucositis in pediatric patients undergoing hematopoietic stem cell transplantation: a double blind randomized clinical trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022Trial
- International field testing of the psychometric properties of an EORTC quality of life module for oral health: the EORTC QLQ-OH15.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016Trial
- Multicenter phase II study of an oral care program for patients with head and neck cancer receiving chemoradiotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016Trial
- The effect of eating sea cucumber jelly on Candida load in the oral cavity of elderly individuals in a nursing home.Marine drugs · 2013Trial
- Sicca symptoms and their impact on quality of life among very long-term survivors after hematopoietic SCT.Bone marrow transplantation · 2013Trial
- Antimicrobial Properties of Freeze-Dried Hyaluronic Acid Sheets Containing Persimmon Tannin.International journal of molecular sciences · 2026Article
- The Role of Dental Oncology in Cancer Care: a Critical Component of Comprehensive Treatment, Education, and Interdisciplinary Collaboration- a Narrative Review.Journal of cancer education : the official journal of the American Association for Cancer Education · 2026Review
- Proactive preventive dental care to maintain eating function in palliative care: a narrative review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Review
- Radiation-induced oral side effects in head and neck cancer: a scoping review and interdisciplinary recommendations.BMC oral health · 2026Article
- Review
- Isolation, identification, and characterization of Candida species isolated from oral specimens of cancer patients and healthy individuals; a cohort study in Galle District, Sri Lanka.BMC oral health · 2025Article
- Article
- Article
- ASSESSMENT OF ORO-DENTAL HEALTH PARAMETERS, FUNGAL INFECTION AND THE SEVERITY OF CHEMOTHERAPY INDUCED - ORAL MUCOSITIS: FINDINGS FROM A SOUTHWESTERN NIGERIAN TERTIARY CARE CENTRE.Annals of Ibadan postgraduate medicine · 2025Article
- The Prevalence and Drug Susceptibility ofAntibiotics (Basel, Switzerland) · 2025Article
- US expert Delphi consensus on the prevention and management of stomatitis in patients treated with datopotamab deruxtecan.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025Article
- Chronic Oral Complications of Oral Cancer Therapy.Dental clinics of North America · 2025Review
45 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 9 institutions in 3 countries.
Funding
Abstract
purposeThe aims of this systematic review were to determine, in patients receiving cancer therapy, the prevalence of clinical oral fungal infection and fungal colonization, to determine the impact on quality of life and cost of care, and to review current management strategies for oral fungal infections.
methodsThirty-nine articles that met the inclusion/exclusion criteria were independently reviewed by two calibrated reviewers, each using a standard form. Information was extracted on a number of variables, including study design, study population, sample size, interventions, blinding, outcome measures, methods, results, and conclusions for each article. Areas of discrepancy between the two reviews were resolved by consensus. Studies were weighted as to the quality of the study design, and recommendations were based on the relative strength of each paper. Statistical analyses were performed to determine the weighted prevalence of clinical oral fungal infection and fungal colonization.
resultsFor all cancer treatments, the weighted prevalence of clinical oral fungal infection was found to be 7.5% pre-treatment, 39.1% during treatment, and 32.6% after the end of cancer therapy. Head and neck radiotherapy and chemotherapy were each independently associated with a significantly increased risk for oral fungal infection. For all cancer treatments, the prevalence of oral colonization with fungal organisms was 48.2% before treatment, 72.2% during treatment, and 70.1% after treatment. The prophylactic use of fluconazole during cancer therapy resulted in a prevalence of clinical fungal infection of 1.9%. No information specific to oral fungal infections was found on quality of life or cost of care.
conclusionsThere is an increased risk of clinically significant oral fungal infection during cancer therapy. Systemic antifungals are effective in the prevention of clinical oral fungal infection in patients receiving cancer therapy. Currently available topical antifungal agents are less efficacious, suggesting a need for better topical agents.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.