ArticleJournal of cancer research and clinical oncology2011
Influence of TGFB1+869T>C functional polymorphism in non-small cell lung cancer (NSCLC) risk.
Article in Journal of cancer research and clinical oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Transforming growth factor-β1 rs1800470 polymorphism is associated with lung cancer risk: a meta-analysis.Medical science monitor : international medical journal of experimental and clinical research · 2014Pooled it
- Association of regulatory B, T cells and cytokine production with disease stage in non-small cell lung cancer patients: prospective case control study.BMC cancer · 2026Article
- The Role of Tumor Inflammatory Microenvironment in Lung Cancer.Frontiers in pharmacology · 2021Review
- TGFβ1: An Indicator for Tumor Immune Microenvironment of Colon Cancer From a Comprehensive Analysis of TCGA.Frontiers in genetics · 2021Article
- Identifying Common Genes Related to Platelet and Immunity for Lung Adenocarcinoma Prognosis Prediction.Frontiers in molecular biosciences · 2020Article
- Adverse prognostic impact ofOncoTargets and therapy · 2017Article
- Molecular and Cellular Effects of Hydrogen Peroxide on Human Lung Cancer Cells: Potential Therapeutic Implications.Oxidative medicine and cellular longevity · 2016Review
- TGF-β1 C-509T and T869C polymorphisms and cancer risk: a meta analysis.International journal of clinical and experimental medicine · 2015Article
- Apoptosis-Related Single Nucleotide Polymorphisms and the Risk of Non-Small Cell Lung Cancer in Women.Journal of cancer therapeutics & research · 2014Article
- TGF-beta specifically enhances the metastatic attributes of murine lung adenocarcinoma: implications for human non-small cell lung cancer.Clinical & experimental metastasis · 2013Article
- Systematic evaluation of apoptotic pathway gene polymorphisms and lung cancer risk.Carcinogenesis · 2012Article
- EGFR signaling pathway and related-miRNAs in age-related diseases: the example of miR-221 and miR-222.Frontiers in genetics · 2012Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeLung cancer is the third most common type of cancer in Europe and is the first cause of death by cancer worldwide. Non-small cell lung cancer accounts for 75-85% of all histological types of LC. The transforming growth factor beta 1 is a multifunctional regulatory polypeptide that controls many aspects of cellular function (cellular proliferation, differentiation, migration, apoptosis, immune surveillance). TGFB1+869T>C is a functional polymorphism described in TGFB1 gene and this transition has been associated with higher circulating levels of TGFß1 that may modulate cellular microenvironment and consequently LC development and prognosis.
methodsWe studied TGFB + 869T > C functional polymorphism by allelic discrimination using 7300 real-time polymerase chain reaction system in 305 patients with NSCLC and 380 healthy individuals.
resultsWe found an increased risk for C carriers to develop NSCLC, both epidermoid NSCLC and non-epidermoid NSCLC (odds ratio (OR) = 2.03, P < 0.0001, OR = 2.37, P < 0.001 and OR = 1.83, P = 0.001, respectively). TGFB1+869T>C functional polymorphism may influence NSCLC susceptibility with impact in cellular microenvironment.
conclusionsOur results suggest that individual differences influence the susceptibility to LC and tumoral behavior. This genetic profiling may help define higher risk groups for an individualized chemoprevention strategy and therapy.
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