ArticleMicrobial ecology2010
Molecular and microscopical investigation of the microflora inhabiting a deteriorated Italian manuscript dated from the thirteenth century.
Article in Microbial ecology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 112 citations in OpenAlex.
- An integration of bacterial probiotic extract and green nanoparticles as a safe approach for conservation of historical manuscript against fungal deterioration: an applied study.Scientific reports · 2026Article
- Metagenomic and microbiological analyses of historical manuscripts for bacterial community profiling and bacteria-related biodeterioration assessment.Microbial cell (Graz, Austria) · 2026Article
- Fungal biodeterioration and preservation of cultural heritage, artwork, and historical artifacts: extremophily and adaptation.Microbiology and molecular biology reviews : MMBR · 2024Review
- Fungal and bacterial species richness in biodeteriorated seventeenth century Venetian manuscripts.Scientific reports · 2024Article
- Antifungal Activity of Cell-Free Filtrate of Probiotic BacteriaMicroorganisms · 2023Article
- Air- and dustborne fungi in repositories of the National Archive of the Republic of Cuba.Microbial cell (Graz, Austria) · 2022Article
- Assessing the microbiological contamination along with environmental factors of old books in the 1490-founded Bistrița Monastery, Romania.Environmental science and pollution research international · 2021Article
- Current Methods, Common Practices, and Perspectives in Tracking and Monitoring Bioinoculants in Soil.Frontiers in microbiology · 2021Review
- The Microbiome of Leonardo da Vinci's Drawings: A Bio-Archive of Their History.Frontiers in microbiology · 2020Article
- Molecular identification of fungi colonizing art objects in Thailand and their growth inhibition by local plant extracts.3 Biotech · 2019Article
- Microbial diversity in biodeteriorated Greek historical documents dating back to the 19th and 20th century: A case study.MicrobiologyOpen · 2018Article
- Melding the Old with the New: Trends in Methods Used to Identify, Monitor, and Control Microorganisms on Cultural Heritage Materials.Microbial ecology · 2018Review
- Microbial Community Analyses of the Deteriorated Storeroom Objects in the Tianjin Museum Using Culture-Independent and Culture-Dependent Approaches.Frontiers in microbiology · 2018Article
- Evaluation of a Parchment Document, the 13th Century Incorporation Charter for the City of Krakow, Poland, for Microbial Hazards.Applied and environmental microbiology · 2016Article
- Microbial communities affecting albumen photography heritage: a methodological survey.Scientific reports · 2016Article
- Amid the possible causes of a very famous foxing: molecular and microscopic insight into Leonardo da Vinci's self-portrait.Environmental microbiology reports · 2015Article
- Unmasking the measles-like parchment discoloration: molecular and microanalytical approach.Environmental microbiology · 2015Article
- The community distribution of bacteria and fungi on ancient wall paintings of the Mogao Grottoes.Scientific reports · 2015Article
- A combined approach to assess the microbial contamination of the archimedes palimpsest.Microbial ecology · 2015Article
- Synergistic combination of violacein and azoles that leads to enhanced killing of major human pathogenic dermatophytic fungi Trichophyton rubrum.Frontiers in cellular and infection microbiology · 2015Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
This case study shows the application of nontraditional diagnostic methods to investigate the microbial consortia inhabiting an ancient manuscript. The manuscript was suspected to be biologically deteriorated and SEM observations showed the presence of fungal spores attached to fibers, but classic culturing methods did not succeed in isolating microbial contaminants. Therefore, molecular methods, including PCR, denaturing gradient gel electrophoresis (DGGE), and clone libraries, were used as a sensitive alternative to conventional cultivation techniques. DGGE fingerprints revealed a high biodiversity of both bacteria and fungi inhabiting the manuscript. DNA sequence analysis confirmed the existence of fungi and bacteria in manuscript samples. A number of fungal clones identified on the manuscript showed similarity to fungal species inhabiting dry or saline environments, suggesting that the manuscript environment selects for osmophilic or xerophilic fungal species. Most of the bacterial sequences retrieved from the manuscript belong to phylotypes with cellulolytic activities.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.