Evidence map›Paper›PMID 20449256›Full record

ArticleChemical communications (Cambridge, England)2010

DNA-polyfluorophore excimers as sensitive reporters for esterases and lipases.

Nan Dai, Yin Nah Teo, Eric T Kool

Abstract read
In one paragraph

Article in Chemical communications (Cambridge, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Selective fluorogenic chemosensors for distinct classes of nucleases.Chembiochem : a European journal of chemical biology · 2013
    Article
  4. DNA-multichromophore systems.Chemical reviews · 2012
    Review
  5. Direct fluorescence monitoring of DNA base excision repair.Angewandte Chemie (International ed. in English) · 2012
    Article
  6. Fluorescent DNA-based enzyme sensors.Chemical Society reviews · 2011
    Review
  7. Article
  8. Chemistry of nucleic acids: impacts in multiple fields.Chemical communications (Cambridge, England) · 2011
    Review
  9. Article
  10. Article
  11. Multispectral labeling of antibodies with polyfluorophores on a DNA backbone and application in cellular imaging.Proceedings of the National Academy of Sciences of the United States of America · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Nan DaiDepartment of Chemistry, Stanford University, Stanford, CA 94305, USA.
Yin Nah Teo
Eric T Kool
Stanford University · US

Funding

POLYFLUOROPHORES ASSEMBLED ON A DNA SCAFFOLDR01GM067201 · NIGMS · STANFORD UNIVERSITY · PI KOOL, ERIC T. · 2003 to 2011
$2.2M
NIGMS NIH HHS GM067201NIGMS NIH HHS R01 GM067201
6 · The paper itself

Abstract

DNA-scaffolded oligodeoxyriboside fluorophores (ODFs) were used as the reporters in turn-on sensing of enzymatic bond-cleaving activity. A tetramer ODF of pyrene deoxynucleosides displayed high quenching efficiency when conjugated via ester linkages with a dabcyl quencher, and yielded large signal increases with several enzymes in vitro and in intact human cells.

Indexed as

Biosensing TechniquesDeoxyribonucleosidesDNAEsterasesFluorescent DyesHeLa CellsHumansLipaseMolecular StructureDeoxyribonucleosidesDNAEsterasesFluorescent DyesLipase

Identifiers

PMID20449256
PMCPMC5501962
OpenAlexW2082023242

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.