ReviewWiley interdisciplinary reviews. Systems biology and medicine
Multiscale modeling for biologists.
Review in Wiley interdisciplinary reviews. Systems biology and medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 128 citations in OpenAlex.
- Quantitative Modeling of TLR Signaling Reveals Missing Negative Feedback Guiding Identification of TANK-IKKε Checkpoint.bioRxiv : the preprint server for biology · 2026Article
- Intelligent tool orchestration for rapid mechanistic model prototyping: MCP servers as AI-biology interfaces.NPJ systems biology and applications · 2026Article
- Recent Advances in AI and GenAI for Health Informatics.Healthcare (Basel, Switzerland) · 2026Review
- Emerging Technologies for Exploring the Cellular Mechanisms in Vascular Diseases.International journal of molecular sciences · 2025Review
- The Constrained Disorder Principle: A Paradigm Shift for Accurate Interactome Mapping and Information Analysis in Complex Biological Systems.Bioengineering (Basel, Switzerland) · 2025Review
- Personalised Transdermal Therapy for Chronic Pain with Digital Twin Technology.Current drug targets · 2025Review
- Building multiscale models with PhysiBoSS, an agent-based modeling tool.Briefings in bioinformatics · 2024Article
- Multiscale co-simulation design pattern for neuroscience applications.Frontiers in neuroinformatics · 2024Article
- Intelligent Digital Twins for Personalized Migraine Care.Journal of personalized medicine · 2023Review
- What Is a Digital Twin? Experimental Design for a Data-Centric Machine Learning Perspective in Health.International journal of molecular sciences · 2022Article
- A global method for fast simulations of molecular dynamics in multiscale agent-based models of biological tissues.iScience · 2022Article
- Mathematical modeling of radiotherapy and its impact on tumor interactions with the immune system.Neoplasia (New York, N.Y.) · 2022Review
- Intrinsically Disordered Proteins: Critical Components of the Wetware.Chemical reviews · 2022Review
- Generation of multicellular spatiotemporal models of population dynamics from ordinary differential equations, with applications in viral infection.BMC biology · 2021Article
- A practical guide to mechanistic systems modeling in biology using a logic-based approach.Briefings in bioinformatics · 2021Review
- Modeling Neurotransmission: Computational Tools to Investigate Neurological Disorders.International journal of molecular sciences · 2021Review
- Spiral Wave Propagation in Communities with Spatially Correlated Heterogeneity.Biophysical journal · 2020Article
- Modeling heterogeneous tumor growth dynamics and cell-cell interactions at single-cell and cell-population resolution.Current opinion in systems biology · 2019Article
- Illuminating the Numbers: Integrating Mathematical Models to Optimize Photomedicine Dosimetry and Combination Therapies.Frontiers in physics · 2019Article
- The Spectrum of Mechanism-Oriented Models and Methods for Explanations of Biological Phenomena.Processes (Basel, Switzerland) · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Biomedical research frequently involves performing experiments and developing hypotheses that link different scales of biological systems such as, for instance, the scales of intracellular molecular interactions to the scale of cellular behavior and beyond to the behavior of cell populations. Computational modeling efforts that aim at exploring such multiscale systems quantitatively with the help of simulations have to incorporate several different simulation techniques because of the different time and space scales involved. Here, we provide a nontechnical overview of how different scales of experimental research can be combined with the appropriate computational modeling techniques. We also show that current modeling software permits building and simulating multiscale models without having to become involved with the underlying technical details of computational modeling.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.