Evidence map›Paper›PMID 20448658›Full record

ReviewNature reviews. Urology2010

Epidemiology and risk factors for kidney cancer.

Wong-Ho Chow, Linda M Dong, Susan S Devesa

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nature reviews. Urology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05785052 (Biomarkers of Renal Cancer), which is not on this map. Cited by 667 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
667citing papers in PubMed, 8 pooled it
50.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05785052 unknown statusnot on this mapstarted 2019, after this paper: background citation

Biomarkers of Renal Cancer

TypeobservationalSponsorBiorek S.R.L.Ran2019 to 2026Enrolled1,000ConditionsRenal Cell Carcinoma, Tumor, Solid, Oncocytoma, Angiomyolipoma
3 · Its place in the literature

Who cites it

667 citing papers in PubMed, 8 syntheses or guidelines pooled it, 1,409 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Occupational benzene exposure and risk of kidney and bladder cancers: a systematic review and meta-analysis.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2025
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. SEOM SOGUG clinical guideline for treatment of kidney cancer (2022).Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023
    Guideline
  9. Trial
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Urolithiasis in patients with cancer.Nature reviews. Urology · 2026
    Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Observational

607 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Wong-Ho ChowDivision of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD 20892-7240, USA. choww@mail.nih.gov <choww@mail.nih.gov>
Linda M Dong
Susan S Devesa
Department of Health and Human Services · USNational Cancer Institute · USNational Institutes of Health · US

Funding

Cancer Risk in Human PopulationsZIACP010136 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI PURDUE, MARK · 2009 to 2025
$36.7M
Intramural NIH HHS ZIA CP010136
6 · The paper itself

Abstract

After more than two decades of rising rates, in recent years the total kidney cancer incidence worldwide has shown signs of stabilizing, or even decreasing. In adults, kidney cancer consists of renal cell carcinoma (RCC), the predominant form, and renal transitional cell carcinoma (RTCC); these types primarily arise in the renal parenchyma and renal pelvis, respectively. Although temporal trends by kidney cancer type are not well established worldwide, incidence of RCC in the US has continued to rise, mainly for early-stage tumors, while that of RTCC has declined, and total kidney cancer mortality rates have leveled. Stabilization of kidney cancer mortality rates has also been reported in Europe. These trends are consistent with reports of increasing incidental diagnoses and a downward shift in tumor stage and size in clinical series. The changing prevalence of known risk factors for RCC, including cigarette smoking, obesity, and hypertension, is also likely to affect incidence trends, although their relative impact may differ between populations. Accumulating evidence suggests an etiologic role in RCC for physical activity, alcohol consumption, occupational exposure to trichloroethylene, and high parity among women, but further research is needed into the potential causal effects of these factors. Genetic factors and their interaction with environmental exposures are believed to influence risk of developing RCC, but a limited number of studies using candidate-gene approaches have not produced conclusive results. Large consortium efforts employing genome-wide scanning technology are underway, which hold promise for novel discoveries in renal carcinogenesis.

Indexed as

Carcinoma, Renal CellCarcinoma, Transitional CellDietEnvironmental ExposureFemaleGenetic Predisposition to DiseaseGlobal HealthHumansHypertensionIncidenceKidney NeoplasmsMotor ActivityObesityOccupational ExposureParityPregnancy

Identifiers

PMID20448658
PMCPMC3012455
OpenAlexW1976043651

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.