ArticleJournal of human genetics2010
The regulation-of-autophagy pathway may influence Chinese stature variation: evidence from elder adults.
Article in Journal of human genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Compounds isolated fromSaudi journal of biological sciences · 2020Article
- Autophagy Regulates Craniofacial Bone Acquisition.Calcified tissue international · 2019Article
- Vitamin K2 stimulates MC3T3‑E1 osteoblast differentiation and mineralization through autophagy induction.Molecular medicine reports · 2019Article
- Autophagy in bone homeostasis and the onset of osteoporosis.Bone research · 2019Article
- Autophagy as a target for glucocorticoid-induced osteoporosis therapy.Cellular and molecular life sciences : CMLS · 2018Review
- Achondroplasia: Development, pathogenesis, and therapy.Developmental dynamics : an official publication of the American Association of Anatomists · 2017Review
- Pathway-Based Genome-Wide Association Studies for Two Meat Production Traits in Simmental Cattle.Scientific reports · 2015Article
- Autophagy--a key player in cellular and body metabolism.Nature reviews. Endocrinology · 2014Review
- Article
- Suppression of autophagy by FIP200 deletion leads to osteopenia in mice through the inhibition of osteoblast terminal differentiation.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2013Article
- Autophagy proteins regulate the secretory component of osteoclastic bone resorption.Developmental cell · 2011Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 2 countries.
Funding
Abstract
Recent success of genome-wide association studies (GWASs) on human height variation emphasized the effects of individual loci or genes. In this study, we used a developed pathway-based approach to further test biological pathways for potential association with stature, by examining approximately 370,000 single-nucleotide polymorphisms (SNPs) across the human genome in 618 unrelated elder Han Chinese. A total of 626 biological pathways annotated by any of the three major public pathway databases (KEGG, BioCarta and Ambion GeneAssist Pathway Atlas) were tested. The regulation-of-autophagy (ROA) (nominal P=0.012) pathway was marginally significantly associated with human stature after our family wise error rate multiple-testing correction. We also used 1000 random recruited US whites for further replication. Interestingly, the ROA pathway presented the strongest signals in whites for height variation (nominal P=0.002). The results correspond to biological roles of the ROA pathway in human long bone development and growth. Our findings also implied that multiple-genetic factors may work jointly as a functional unit (pathway), and the traditional GWASs could have missed important genetic information imbedded in those less significant markers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.