ArticleCell adhesion & migration
Polyamine-dependent activation of Rac1 is stimulated by focal adhesion-mediated Tiam1 activation.
Article in Cell adhesion & migration. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- S-Ketamine Exerts Antidepressant Effects by Regulating Rac1 GTPase Mediated Synaptic Plasticity in the Hippocampus of Stressed Rats.Cellular and molecular neurobiology · 2023Article
- Src activation by Chk1 promotes actin patch formation and prevents chromatin bridge breakage in cytokinesis.The Journal of cell biology · 2018Article
- Calcium/Ask1/MKK7/JNK2/c-Src signalling cascade mediates disruption of intestinal epithelial tight junctions by dextran sulfate sodium.The Biochemical journal · 2015Article
- Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis.Cell reports · 2014Article
- Cyclin-dependent kinases regulate apoptosis of intestinal epithelial cells.Apoptosis : an international journal on programmed cell death · 2014Article
- Inhibition of Rac and ROCK signalling influence osteoblast adhesion, differentiation and mineralization on titanium topographies.PloS one · 2013Article
- Finding the weakest link: exploring integrin-mediated mechanical molecular pathways.Journal of cell science · 2012Review
- Spermine, a molecular switch regulating EGFR, integrin β3, Src, and FAK scaffolding.Cellular signalling · 2012Article
- Novel mechanistic link between focal adhesion remodeling and glucose-stimulated insulin secretion.The Journal of biological chemistry · 2012Article
- Heterotrimeric G proteins, focal adhesion kinase, and endothelial barrier function.Microvascular research · 2012Review
- Activation of Dbl restores migration in polyamine-depleted intestinal epithelial cells via Rho-GTPases.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- The phosphorylation state of MRLC is polyamine dependent in intestinal epithelial cells.American journal of physiology. Cell physiology · 2011Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Integrin receptors cluster on the cell surface and bind to extra cellular matrix (ECM) proteins triggering the formation of focal contacts and the activation of various signal transduction pathways that affect the morphology, motility, gene expression and survival of adherent cells. Polyamine depletion prevents the increase in autophosphorylation of focal adhesion kinase (FAK) and Src during attachment. Rac activity also shows a steady decline, and its upstream guanine nucleotide exchange factor (GEF), Tiam1 also shows a reduction in total protein level when cells are depleted of polyamines. When Tiam1 and Rac1 interaction was inhibited by NSC-23766, there was not only a decrease in Rac1 activity as expected but also a decrease in FAK auto-phosphorylation. Inhibition of Src activity by PP2 also reduced FAK autophosphorylation, which implies that Src modulates FAK autophosphorylation. From the data obtained in this study we conclude that FAK and Src are rapidly activated upon fibronectin mediated signaling leading to Tiam1-mediated Rac1 activation and that intracellular polyamines influence the signaling strength by modulating interaction of Src with Tiam1 using focal adhesion kinase as a scaffolding site.
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Registered trials
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