ArticlePrion
Generation of prions in vitro and the protein-only hypothesis.
Article in Prion. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- New views on the complex interplay between degeneration and autoimmunity in multiple sclerosis.Frontiers in cellular neuroscience · 2024Article
- Prion strains: shining new light on old concepts.Cell and tissue research · 2023Review
- Pathological Proteins Are Transported by Extracellular Vesicles of Sporadic Amyotrophic Lateral Sclerosis Patients.Frontiers in neuroscience · 2018Article
- Amyloidogenic cross-seeding of Tau protein: Transient emergence of structural variants of fibrils.PloS one · 2018Article
- Article
- The emergence of superstructural order in insulin amyloid fibrils upon multiple rounds of self-seeding.Scientific reports · 2016Article
- Strain-dependent profile of misfolded prion protein aggregates.Scientific reports · 2016Article
- The extent of protease resistance of misfolded prion protein is highly dependent on the salt concentration.The Journal of biological chemistry · 2014Article
- Lipid-dependent generation of dual topology for a membrane protein.The Journal of biological chemistry · 2012Article
- Stabilization of a prion strain of synthetic origin requires multiple serial passages.The Journal of biological chemistry · 2012Article
- Is tau ready for admission to the prion club?Prion · 2012Review
- Kosmotropic anions promote conversion of recombinant prion protein into a PrPSc-like misfolded form.PloS one · 2012Article
- Misfolded protein aggregates: mechanisms, structures and potential for disease transmission.Seminars in cell & developmental biology · 2011Review
- The intricate mechanisms of neurodegeneration in prion diseases.Trends in molecular medicine · 2011Review
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Prions are self-propagating proteinaceous infectious agents capable of transmitting disease in the absence of nucleic acids. The nature of the infectious agent in prion diseases has been at the center of passionate debate for the past 30 years. However, recent reports on the in vitro generation of prions have settled all doubts that the misfolded prion protein (PrP(Sc)) is the key component in propagating infectivity. However, we still do not understand completely the mechanism of prion replication and whether or not other cellular factors besides PrP(Sc) are required for infectivity. In this article, we discuss these recent reports under the context of the protein-only hypothesis and their implications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.