ReviewJournal of applied physiology (Bethesda, Md. : 1985)2010
Mechanisms and modifiers of reflex induced cutaneous vasodilation and vasoconstriction in humans.
Review in Journal of applied physiology (Bethesda, Md. : 1985), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
143 citing papers in PubMed, 3 syntheses or guidelines pooled it, 449 citations in OpenAlex.
- Effects of Precooling on Endurance Exercise Performance in the Heat: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Nutrients · 2024Pooled it
- Core Body Temperatures in Intermittent Sports: A Systematic Review.Sports medicine (Auckland, N.Z.) · 2023Pooled it
- Precooling methods and their effects on athletic performance : a systematic review and practical applications.Sports medicine (Auckland, N.Z.) · 2013Pooled it
- Intensity and volume of physical exercise influence DOMS and skin temperature differently in healthy adults.Scientific reports · 2024Trial
- Exposure to passive heat and cold stress differentially modulates cerebrovascular-COJournal of applied physiology (Bethesda, Md. : 1985) · 2024Trial
- Deep transcranial magnetic stimulation in combination with skin thermography in obesity: a window on sympathetic nervous system.Acta diabetologica · 2022Trial
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- β-Adrenergic blockade does not impair the skin blood flow sensitivity to local heating in burned and nonburned skin under neutral and hot environments in children.Microcirculation (New York, N.Y. : 1994) · 2017Trial
- A new method of infrared thermography for quantification of brown adipose tissue activation in healthy adults (TACTICAL): a randomized trial.The journal of physiological sciences : JPS · 2017Trial
- Does attenuated skin blood flow lower sweat rate and the critical environmental limit for heat balance during severe heat exposure?Experimental physiology · 2017Trial
- Hemodynamic Stability to Surface Warming and Cooling During Sustained and Continuous Simulated Hemorrhage in Humans.Shock (Augusta, Ga.) · 2016Trial
- The influence of internal and skin temperatures on active cutaneous vasodilation under different levels of exercise and ambient temperatures in humans.International journal of biometeorology · 2013Trial
- Thermoregulation and thermography in neonatal physiology and disease.Biological research for nursing · 2011Trial
- Spurious Fingertip Oxygen Desaturation During the 6-Minute Walk Test in a Patient With NSIP and Raynaud Phenomenon: The Value of Forehead Pulse Oximetry and Transcutaneous Oxygen Tension.Respirology case reports · 2026Article
- The effects of carbonated cold water immersion of the arm during half-time on intermittent exercise performance in the heat.European journal of applied physiology · 2026Article
- Ipsilateral and contralateral microvascular kinetics during unilateral forearm cold-water immersion: a within-subject laser Doppler flowmetry and heart rate variability study.European journal of applied physiology · 2026Article
- Mechanisms of Heat-Induced Sleep Disruption in Aging: A Narrative Review.Clocks & sleep · 2026Review
- The Impact of Additional Respiratory Dead Space Volume Mask During Warm-Up on Skin Blood Flow and Choice Reaction Time in Cyclists: A Randomized Crossover Trial.Journal of clinical medicine · 2026Article
83 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Human skin blood flow responses to body heating and cooling are essential to the normal processes of physiological thermoregulation. Large increases in skin blood flow provide the necessary augmentation of convective heat loss during environmental heat exposure and/or exercise, just as reflex cutaneous vasoconstriction is key to preventing excessive heat dissipation during cold exposure. In humans, reflex sympathetic innervation of the cutaneous circulation has two branches: a sympathetic noradrenergic vasoconstrictor system, and a non-noradrenergic active vasodilator system. Noradrenergic vasoconstrictor nerves are tonically active in normothermic environments and increase their activity during cold exposure, releasing both norepinephrine and cotransmitters (including neuropeptide Y) to decrease skin blood flow. The active vasodilator system in human skin does not exhibit resting tone and is only activated during increases in body temperature, such as those brought about by heat exposure or exercise. Active cutaneous vasodilation occurs via cholinergic nerve cotransmission and has been shown to include potential roles for nitric oxide, vasoactive intestinal peptide, prostaglandins, and substance P (and/or neurokinin-1 receptors). It has proven both interesting and challenging that no one substance has been identified as the sole mediator of active cutaneous vasodilation. The processes of reflex cutaneous vasodilation and vasoconstriction are both modified by acute factors, such as exercise and hydration, and more long-term factors, such as aging, reproductive hormones, and disease. This review will highlight some of the recent findings in these areas, as well as interesting areas of ongoing and future work.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.