ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2010
Plasma folate, related genetic variants, and colorectal cancer risk in EPIC.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 8 of them syntheses that pooled it.
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Who cites it
41 citing papers in PubMed, 8 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Meta Analysis of Methylenetetrahydrofolate Reductase (MTHFR) C677T polymorphism and its association with folate and colorectal cancer.BMC cancer · 2025Pooled it
- Unveiling the link: Evaluating MTHFR gene polymorphisms and colorectal cancer risk through meta-analysis.PloS one · 2025Pooled it
- Pooled it
- Methylenetetrahydrofolate reductase C677T polymorphism and colorectal cancer susceptibility: a meta-analysis.Bioscience reports · 2017Pooled it
- Lack of association between methionine synthase A2756G polymorphism and digestive system cancer risk: evidence from 3,9327 subjects.PloS one · 2013Pooled it
- Methionine synthase A2756G polymorphism and risk of colorectal adenoma and cancer: evidence based on 27 studies.PloS one · 2013Pooled it
- Pooled it
- MTHFR C677T polymorphism contributes to colorectal cancer susceptibility: evidence from 61 case-control studies.Molecular biology reports · 2012Pooled it
- Homocysteine lowering by folate-rich diet or pharmacological supplementations in subjects with moderate hyperhomocysteinemia.Nutrients · 2013Trial
- One-carbon metabolism in cancer: moonlighting functions of metabolic enzymes and anti-tumor therapy.Cancer metastasis reviews · 2025Review
- Nutrition, Environment, and Genetics in Colorectal Cancer. Epigenetics and Possible Future Perspective.Current nutrition reports · 2025Review
- Scientific opinion on the tolerable upper intake level for folate.EFSA journal. European Food Safety Authority · 2023Article
- Genome-wide interaction analysis of folate for colorectal cancer risk.The American journal of clinical nutrition · 2023Article
- The Roles ofNutrients · 2022Article
- Folic Acid Supplement Intake and Risk of Colorectal Cancer in Women; A Case Control Study.Annals of global health · 2020Article
- One-carbon metabolite ratios as functional B-vitamin markers and in relation to colorectal cancer risk.International journal of cancer · 2019Article
- Review
- Circulating folate levels and colorectal adenoma: a case-control study and a meta-analysis.Nutrition research and practice · 2017Article
- Review
- Untangling the role of one-carbon metabolism in colorectal cancer risk: a comprehensive Bayesian network analysis.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
47 authors at 11 institutions in 6 countries.
Funding
Abstract
backgroundA potential dual role of folate in colorectal cancer (CRC) is currently subject to debate. We investigate the associations between plasma folate, several relevant folate-related polymorphisms, and CRC risk within the large European Prospective Investigation into Cancer and Nutrition cohort.
methodsIn this nested case-control study, 1,367 incident CRC cases were matched to 2,325 controls for study center, age, and sex. Risk ratios (RR) were estimated with conditional logistic regression and adjusted for smoking, education, physical activity, and intake of alcohol and fiber.
resultsOverall analyses did not reveal associations of plasma folate with CRC. The RR (95% confidence interval; Ptrend) for the fifth versus the first quintile of folate status was 0.94 (0.74-1.20; 0.44). The polymorphisms MTHFR677C-->T, MTHFR1298A-->C, MTR2756A-->G, MTRR66A-->G, and MTHFD11958G-->A were not associated with CRC risk. However, in individuals with the lowest plasma folate concentrations, the MTHFR 677TT genotype showed a statistically nonsignificant increased CRC risk [RR (95% CI; Ptrend) TT versus CC=1.39 (0.87-2.21); 0.12], whereas those with the highest folate concentrations showed a nonsignificant decreased CRC risk [RR TT versus CC=0.74 (0.39-1.37); 0.34]. The SLC19A180G-->A showed a positive association with CRC risk [RR AA versus GG 1.30 (1.06-1.59); <0.01].
conclusionsThis large European prospective multicenter study did not show an association of CRC risk with plasma folate status nor with MTHFR polymorphisms. IMPACT: Findings of the present study tend to weaken the evidence that folate plays an important role in CRC carcinogenesis. However, larger sample sizes are needed to adequately address potential gene-environment interactions.
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