ReviewCurrent opinion in pharmacology2010
Emerging strategies to boost thymic function.
Review in Current opinion in pharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 78 citations in OpenAlex.
- Thymic evolution on serial CT in glucocorticoid-treated pediatric pneumonia: a retrospective analysis.BMC pediatrics · 2026Article
- KLF2 controls thymic epithelial cell homeostasis, impacting regulatory T cell development and immune tolerance.iScience · 2026Article
- Understanding immune checkpoint inhibitors-related myocarditis: Mechanisms and targeted therapeutic pathways.Theranostics · 2026Review
- Relevance of Recent Thymic Emigrants Following Allogeneic Hematopoietic Cell Transplantation for Pediatric Patients with Inborn Errors of Immunity.Transplantation and cellular therapy · 2025Article
- Foxo3 regulates cortical and medullary thymic epithelial cell homeostasis with implications in T cell development.Cell death & disease · 2024Article
- SARS-CoV-2 variants induce distinct disease and impact in the bone marrow and thymus of mice.iScience · 2023Article
- Effect of GnRH immunocastration on immune function in male rats.Frontiers in immunology · 2022Article
- Thymus Degeneration and Regeneration.Frontiers in immunology · 2021Review
- The Early Postnatal Life: A Dynamic Period in Thymic Epithelial Cell Differentiation.Frontiers in immunology · 2021Review
- RANK Signaling in the Differentiation and Regeneration of Thymic Epithelial Cells.Frontiers in immunology · 2020Review
- T cell receptor excision circles as a tool for evaluating thymic function in young children.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2019Article
- Stochastic modeling of tumor progression and immune evasion.Journal of theoretical biology · 2018Article
- A novel approach to improve immune effector responses post transplant by restoration of CCL21 expression.PloS one · 2018Article
- Administration of RANKL boosts thymic regeneration upon bone marrow transplantation.EMBO molecular medicine · 2017Article
- Prolongevity hormone FGF21 protects against immune senescence by delaying age-related thymic involution.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Thymic and Postthymic Regulation of Naïve CD4(+) T-Cell Lineage Fates in Humans and Mice Models.Mediators of inflammation · 2016Review
- Effect of IL-7 Therapy on Naive and Memory T Cell Homeostasis in Aged Rhesus Macaques.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Interleukin-22: immunobiology and pathology.Annual review of immunology · 2015Review
- Gene profiling reveals association between altered Wnt signaling and loss of T-cell potential with age in human hematopoietic stem cells.Aging cell · 2014Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
The thymus constitutes the primary lymphoid organ for the generation of T cells. Its function is particularly susceptible to various negative influences ranging from age-related involution to atrophy as a consequence of malnutrition, infection or harmful iatrogenic influences such as chemotherapy and radiation. The loss of regular thymus function significantly increases the risk for infections and cancer because of a restricted capacity for immune surveillance. In recent years, thymus-stimulatory, thymus-regenerative, and thymus-protective strategies have been developed to enhance and repair thymus function in the elderly and in individuals undergoing hematopoietic stem cell transplantation. These strategies include the use of sex steroid ablation, the administration of growth and differentiation factors, the inhibition of p53, and the transfer of T cell progenitors to alleviate the effects of thymus dysfunction and consequent T cell deficiency.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.