ArticleThe Journal of nutritional biochemistry2011
An extract of Artemisia dracunculus L. enhances insulin receptor signaling and modulates gene expression in skeletal muscle in KK-A(y) mice.
Article in The Journal of nutritional biochemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 60 citations in OpenAlex.
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- Traditional uses, Phytochemistry, Pharmacology, and Toxicology of the GenusCurrent topics in medicinal chemistry · 2024Review
- Extract ofInternational journal of molecular sciences · 2023Article
- Plant Bioactives in the Treatment of Inflammation of Skeletal Muscles: A Molecular Perspective.Evidence-based complementary and alternative medicine : eCAM · 2022Review
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- Bioactive compounds from Artemisia dracunculus L. activate AMPK signaling in skeletal muscle.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2021Article
- Possible Synergistic Antidiabetic Effects of QuantifiedBiology · 2021Article
- Phytochemistry and pharmacological activity of the genus artemisia.Archives of pharmacal research · 2021Review
- Designing a Clinical Study With Dietary Supplements: It's All in the Details.Frontiers in nutrition · 2021Article
- Adaptive Fat Oxidation Is Coupled with Increased Lipid Storage in Adipose Tissue of Female Mice Fed High Dietary Fat and Sucrose.Nutrients · 2020Article
- The DESIGNER Approach Helps Decipher the Hypoglycemic Bioactive Principles ofJournal of natural products · 2019Article
- Potential adverse effects of botanical supplementation in high-fat-fed female mice.Biology of sex differences · 2018Article
- An Extract of Russian Tarragon Prevents Obesity-Related Ectopic Lipid Accumulation.Molecular nutrition & food research · 2018Article
- An Extract ofOxidative medicine and cellular longevity · 2018Article
- Caffeic Acid Attenuates Diabetic Kidney Disease via Modulation of Autophagy in a High-Fat Diet/Streptozotocin- Induced Diabetic Rat.Scientific reports · 2017Article
- DNA Microarray-Based Screening and Characterization of Traditional Chinese Medicine.Microarrays (Basel, Switzerland) · 2017Review
- An extract of Artemisia dracunculus L. stimulates insulin secretion from β cells, activates AMPK and suppresses inflammation.Journal of ethnopharmacology · 2015Article
- Magnolia officinalis Extract Contains Potent Inhibitors against PTP1B and Attenuates Hyperglycemia in db/db Mice.BioMed research international · 2015Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
An ethanolic extract of Artemisia dracunculus L. (PMI 5011) has been observed to decrease glucose and insulin levels in animal models, but the cellular mechanisms by which insulin action is enhanced in vivo are not precisely known. In this study, we evaluated the effects of PMI 5011 to modulate gene expression and cellular signaling through the insulin receptor in skeletal muscle of KK-A(y) mice. Eighteen male KK-A(y) mice were randomized to a diet (w/w) mixed with PMI 5011 (1%) or diet alone for 8 weeks. Food intake, adiposity, glucose and insulin were assessed over the study, and at study completion, vastus lateralis muscle was obtained to assess insulin signaling parameters and gene expression. Animals randomized to PMI 5011 were shown to have enhanced insulin sensitivity and increased insulin receptor signaling, i.e., IRS-associated PI-3 kinase activity, Akt-1 activity and Akt phosphorylation, in skeletal muscle when compared to control animals (P<.01, P<.01 and P<.001, respectively). Gene expression for insulin signaling proteins, i.e., IRS-1, PI-3 kinase and Glut-4, was not increased, although a relative increase in protein abundance was noted with PMI 5011 treatment. Gene expression for specific ubiquitin proteins and specific 20S proteasome activity, in addition to skeletal muscle phosphatase activity, i.e., PTP1B activity, was significantly decreased in mice randomized to PMI 5011 relative to control. Thus, the data demonstrate that PMI 5011 increases insulin sensitivity and enhances insulin receptor signaling in an animal model of insulin resistance. PMI 5011 may modulate skeletal muscle protein degradation and phosphatase activity as a possible mode of action.
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