Evidence map›Paper›PMID 20447569›Full record

ReviewTrends in cardiovascular medicine2009

Autoregulation of cardiac l-type calcium channels.

Jonathan Satin, Elizabeth A Schroder

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in cardiovascular medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Molecular Regulation of Cardiomyocyte Maturation.Current cardiology reports · 2025
    Review
  3. Sertraline-induced 5-HT dysregulation in mouse cardiomyocytes and the impact on calcium handling.American journal of physiology. Heart and circulatory physiology · 2024
    Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jonathan SatinDepartment of Physiology, MS508 University of Kentucky College of Medicine, Lexington, KY 40536-0298, USA. jsatin1@uky.edu
Elizabeth A Schroder
University of Kentucky · US

Funding

Mechanisms of Long-term Cardiac Ion Channel RegulationR01HL074091 · NHLBI · UNIVERSITY OF KENTUCKY · PI SATIN, JONATHAN · 2003 to 2013
$3.3M
T35 Short Term Research Training GrantT35HL007491 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SAVOIA, MARIA CHRISTINA · 1985 to 2015
$2.8M
NHLBI NIH HHS HL-07491NHLBI NIH HHS R01 HL074091NHLBI NIH HHS T35 HL007491
6 · The paper itself

Abstract

l-Type calcium channels (LTCCs) are major contributors to electrical and contractile function of the heart. They regulate action potential duration, enable calcium entry into cardiac myocytes for contraction, and regulate growth-related signaling in the heart. In cardiac development and in mature heart disease, LTCCs are regulated at levels of acute function and transcription. In addition, LTCCs are clinically relevant therapeutic targets for antihypertensive medications. In this review, we discuss LTCC homeostasis whereby cardiac myocytes maintain LTCC expression via a novel transcriptionally regulated pathway that includes a segment of the LTCC that moves between surface membrane and nucleus.

Indexed as

Calcium SignalingAnimalsCalcium Channels, L-TypeHomeostasisHumansMyocardiumPromoter Regions, GeneticProtein TransportTranscription, GeneticCalcium Channels, L-TypeL-type calcium channel alpha(1C)

Identifiers

PMID20447569
PMCPMC2867252
OpenAlexW2047790766

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.