ArticleChemistry and physics of lipids2010
Structure and water permeability of fully hydrated diphytanoylPC.
Article in Chemistry and physics of lipids, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 94 citations in OpenAlex.
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- Lung SPLUNC1 Peptide Derivatives in the Lipid Membrane Headgroup Kill Gram-Negative Planktonic and Biofilm Bacteria.Biomacromolecules · 2023Article
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- Effect of Cobalt Ferrite Nanoparticles in a Hydrophilic Shell on the Conductance of Bilayer Lipid Membrane.Membranes · 2022Article
- Small-Angle Neutron Scattering for Studying Lipid Bilayer Membranes.Biomolecules · 2022Review
- Cell-Free Expression to Probe Co-Translational Insertion of an Alpha Helical Membrane Protein.Frontiers in molecular biosciences · 2022Article
- Structural and mechanical properties of the red blood cell's cytoplasmic membrane seen through the lens of biophysics.Frontiers in physiology · 2022Review
- Dynorphin A induces membrane permeabilization by formation of proteolipidic pores. Insights from electrophysiology and computational simulations.Computational and structural biotechnology journal · 2022Article
- Binding of DNA origami to lipids: maximizing yield and switching via strand displacement.Nucleic acids research · 2021Article
- Non-Polar Lipids as Regulators of Membrane Properties in Archaeal Lipid Bilayer Mimics.International journal of molecular sciences · 2021Article
- Mechanical properties of ester- and ether-DPhPC bilayers: A molecular dynamics study.Journal of the mechanical behavior of biomedical materials · 2021Article
- Helically shaped cation receptor: design, synthesis, characterisation and first application to ion transport.RSC advances · 2020Article
- Structural Characterization of an Archaeal Lipid Bilayer as a Function of Hydration and Temperature.International journal of molecular sciences · 2020Article
- The Effect of Buffers on Weak Acid Uptake by Vesicles.Biomolecules · 2019Article
- Lipid Headgroup Charge and Acyl Chain Composition Modulate Closure of Bacterial β-Barrel Channels.International journal of molecular sciences · 2019Article
- Effect of late endosomal DOBMP lipid and traditional model lipids of electrophysiology on the anthrax toxin channel activity.Biochimica et biophysica acta. Biomembranes · 2018Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Diphytanoylphosphatidylcholine (DPhyPC) is a branched chain lipid often used for model membrane studies, including peptide/lipid interactions, ion channels and lipid rafts. This work reports results of volume measurements, water permeability measurements P(f), X-ray scattering from oriented samples, and X-ray and neutron scattering from unilamellar vesicles at T=30 degrees C. We measured the volume/lipid V(L)=1426+/-1A(3). The area/lipid was found to be 80.5+/-1.5A(2) when both X-ray and neutron data were combined with the SDP model analysis (Kucerka, N., Nagle, J.F., Sachs, J.N., Feller, S.E., Pencer, J., Jackson, A., Katsaras, J., 2008. Lipid bilayer structure determined by the simultaneous analysis of neutron and X-ray scattering data. Biophys. J. 95, 2356-2367); this is substantially larger than the area of DOPC which has the largest area of the common linear chain lipids. P(f) was measured to be (7.0+/-1.0)x10(-3)cm/s; this is considerably smaller than predicted by the recently proposed 3-slab model (Nagle, J.F., Mathai, J.C., Zeidel, M.L., Tristram-Nagle, S., 2008. Theory of passive permeability through lipid bilayers. J. Gen. Physiol. 131, 77-85). This disagreement can be understood if there is a diminished diffusion coefficient in the hydrocarbon core of DPhyPC and that is supported by previous molecular dynamics simulations (Shinoda, W., Mikami, M., Baba, T., Hato, M., 2004. Molecular dynamics study on the effects of chain branching on the physical properties of lipid bilayers. 2. Permeability. J. Phys. Chem. B 108, 9346-9356). While the DPhyPC head-head thickness (D(HH)=36.4A), and Hamaker parameter (H=4.5x10(-21)J) were similar to the linear chain lipid DOPC, the bending modulus (K(C)=5.2+/-0.5x10(-21)J) was 30% smaller. Our results suggest that, from the biophysical perspective, DPhyPC belongs to a different family of lipids than phosphatidylcholines that have linear chain hydrocarbon chains.
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