ArticleNano letters2010
Targeted cytosolic delivery of cell-impermeable compounds by nanoparticle-mediated, light-triggered endosome disruption.
Article in Nano letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 116 citations in OpenAlex.
- A Comprehensive Review: Mesoporous Silica Nanoparticles Greatly Improve Pharmacological Effectiveness of Phytoconstituent in Plant Extracts.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Targeting the Inside of Cells with Biologicals: Chemicals as a Delivery Strategy.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2021Review
- Review
- An Update on Mesoporous Silica Nanoparticle Applications in Nanomedicine.Pharmaceutics · 2021Review
- Engineered Polymeric Materials for Biological Applications: Overcoming Challenges of the Bio-Nano Interface.Polymers · 2019Review
- Antibody-Drug Conjugate that Exhibits Synergistic Cytotoxicity with an Endosome-Disruptive Peptide.ACS omega · 2019Article
- Mesoporous Silica Nanoparticles: A Comprehensive Review on Synthesis and Recent Advances.Pharmaceutics · 2018Review
- Protein delivery into cells using inorganic nanoparticle-protein supramolecular assemblies.Chemical Society reviews · 2018Review
- Polysaccharide-based nanoparticles for co-loading mitoxantrone and verapamil to overcome multidrug resistance in breast tumor.International journal of nanomedicine · 2017Article
- A DNA dual lock-and-key strategy for cell-subtype-specific siRNA delivery.Nature communications · 2016Article
- Modulation of Silica Nanoparticle Uptake into Human Osteoblast Cells by Variation of the Ratio of Amino and Sulfonate Surface Groups: Effects of Serum.ACS applied materials & interfaces · 2015Article
- Engineering cytochrome-modified silica nanoparticles to induce programmed cell death.Chemistry (Weinheim an der Bergstrasse, Germany) · 2013Article
- Multi-chromatic pH-activatable 19F-MRI nanoprobes with binary ON/OFF pH transitions and chemical-shift barcodes.Angewandte Chemie (International ed. in English) · 2013Article
- Synergistic antitumor activity from two-stage delivery of targeted toxins and endosome-disrupting nanoparticles.Biomacromolecules · 2013Article
- Photochemical mechanisms of light-triggered release from nanocarriers.Advanced drug delivery reviews · 2012Review
- Continuous spectroscopic measurements of photo-stimulated release of molecules by nanomachines in a single living cell.Nanoscale · 2012Article
- Sendai virus-based liposomes enable targeted cytosolic delivery of nanoparticles in brain tumor-derived cells.Journal of nanobiotechnology · 2012Article
- The shape of things to come: importance of design in nanotechnology for drug delivery.Therapeutic delivery · 2012Review
- Improved tumor targeting of polymer-based nanovesicles using polymer-lipid blends.Bioconjugate chemistry · 2011Article
- Molecular theranostics: a primer for the imaging professional.AJR. American journal of roentgenology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Nanoparticle (NP)-mediated drug delivery typically relies on cargo release to occur passively or in response to environmental stimuli. Here we present a delivery method based on light-activated disruption of intracellular vesicles after internalization of biofunctionalized mesoporous silica nanoparticles loaded with cargo. This method combines the power of targeted delivery with the spatiotemporal control of light activation. As an example, we delivered a cell-impermeable fluorescent compound exclusively to the cytosol of multidrug resistant cancer cells in a mixed population.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.