ArticleCellular and molecular neurobiology2010
Interaction of Estrogen Receptor Associated Protein (ERAP) 140 with ER beta decreases but its expression increases in aging mouse cerebral cortex.
Article in Cellular and molecular neurobiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Estrogen Receptor α- and β-Interacting Proteins Contain Consensus Secondary Structures: An Insilico Study.Annals of neurosciences · 2018Article
- TLDc proteins: new players in the oxidative stress response and neurological disease.Mammalian genome : official journal of the International Mammalian Genome Society · 2017Review
- Age-associated Cognitive Decline: Insights into Molecular Switches and Recovery Avenues.Aging and disease · 2016Review
- Regulation of CYP1A1 and Inflammatory Cytokine by NCOA7 Isoform 4 in Response to Dioxin Induced Airway Inflammation.Tuberculosis and respiratory diseases · 2015Article
- Age-dependent Effects of 17β-estradiol on the dynamics of estrogen receptor β (ERβ) protein-protein interactions in the ventral hippocampus.Molecular & cellular proteomics : MCP · 2014Article
- Comparison of α-synuclein immunoreactivity in the hippocampus between the adult and aged beagle dogs.Cellular and molecular neurobiology · 2013Article
- Estrogen receptor β and its domains interact with casein kinase 2, phosphokinase C, and N-myristoylation sites of mitochondrial and nuclear proteins in mouse brain.The Journal of biological chemistry · 2012Article
- Expression of Trk A and Src and their interaction with ERβ ligand binding domain show age and sex dependent alteration in mouse brain.Neurochemical research · 2012Article
- A polymorphism in the nuclear receptor coactivator 7 gene and breast cancer susceptibility.Oncology letters · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Following binding to cognate ligand, estrogen receptor (ER) beta interacts with specific responsive elements of the target genes and recruits a host of nuclear proteins for hormone dependent gene regulation. However, it is poorly known which proteins interact with ER beta in mouse brain and whether their interaction and expression change with age. In this report, we have used his-tag mouse ER beta for interaction with nuclear proteins of cerebral cortex of young (6 +/- 1 weeks), adult (25 +/- 2 weeks), and old (70 +/- 5 weeks) female mice. We have identified estrogen receptor-associated protein (ERAP) 140 as one of the interacting proteins and studied its interaction by pull down immunoblotting, far-Western blotting and immunoprecipitation, and expression by western blotting. The data show that ERAP 140 interacts with ER beta and its interaction decreases but its expression increases with age in mouse cerebral cortex, suggesting its role in estrogen-mediated brain functions during aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.