ArticlePediatric nephrology (Berlin, Germany)2010
Early age at debut is a predictor of steroid-dependent and frequent relapsing nephrotic syndrome.
Article in Pediatric nephrology (Berlin, Germany), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 78 citations in OpenAlex.
- Extending prednisolone treatment does not reduce relapses in childhood nephrotic syndrome.Journal of the American Society of Nephrology : JASN · 2013Trial
- Machine learning prediction of childhood nephrotic syndrome outcomes.Pediatric nephrology (Berlin, Germany) · 2026Observational
- Relapsing childhood steroid sensitive nephrotic syndrome: what determines eventual remission?Pediatric nephrology (Berlin, Germany) · 2026Article
- Age at onset and cumulative initial prednisolone dose predict frequent relapses in steroid-sensitive nephrotic syndrome: an individual participant data systematic review and meta-analysis of placebo-controlled RCTs.Pediatric nephrology (Berlin, Germany) · 2026Review
- Management of Nephrotic Syndrome in Pediatric Patients Treated by Different Steroid Regimens.Medicina (Kaunas, Lithuania) · 2025Article
- Steroid-sensitive nephrotic syndrome: Do children with early onset of <4 years of age, really need standard therapy?Journal of family medicine and primary care · 2025Article
- Time to remission in childhood steroid sensitive nephrotic syndrome: a change in perspective.European journal of pediatrics · 2025Article
- Predictive value of early neutrophil-to-lymphocyte ratio and C-reactive protein in pediatric steroid-sensitive nephrotic syndrome.Frontiers in nephrology · 2025Article
- Timing of relapse as a key indicator of steroid-sparing requirements in childhood idiopathic nephrotic syndrome.Journal of nephrology · 2024Article
- Prediction Model and Decision Analysis for Early Recognition of SDNS/FRNS in Children.Journal of inflammation research · 2024Article
- Treatment of idiopathic nephrotic syndrome at onset: a comparison between 8- and 12-week regimens in everyday clinical practice.Pediatric nephrology (Berlin, Germany) · 2023Article
- Late Onset of ANCA Vasculitis as a Side Effect of Levamisole Treatment in Nephrotic Syndrome.Medicina (Kaunas, Lithuania) · 2022Article
- Infectious complications in children with nephrotic syndrome: Can they be prevented?Medical journal, Armed Forces India · 2022Article
- Update on the treatment of steroid-sensitive nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2022Review
- Optimizing the corticosteroid dose in steroid-sensitive nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2022Review
- Article
- Childhood Idiopathic Nephrotic Syndrome: Does the Initial Steroid Treatment Modify the Outcome? A Multicentre, Prospective Cohort Study.Frontiers in pediatrics · 2021Article
- Prediction of Short- and Long-Term Outcomes in Childhood Nephrotic Syndrome.Kidney international reports · 2020Article
- An evaluation of phase angle, bioelectrical impedance vector analysis and impedance ratio for the assessment of disease status in children with nephrotic syndrome.BMC nephrology · 2019Article
- Safety and Efficacy of Pneumococcal Vaccination in Pediatric Nephrotic Syndrome.Frontiers in pediatrics · 2019Review
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The purpose of this study was to identify characteristics of patients with steroid-sensitive nephrotic syndrome (SSNS) that point to a high risk of frequent relapsing (FR) or steroid-dependent (SD) SSNS. A retrospective analysis of 54 consecutive patients with SSNS was performed. In this cohort, the incidence of idiopathic NS was 1.9/100,000, age at debut was 5.5 years, and the mean follow-up was 4.0 years. A total of 56% (30/54) of our patients were classified with FR/SD SSNS. FR/SD patients were significantly younger at debut than non-FR/SD patients (3.5 vs. 8.5 years, respectively; p < 0.002). Males were overrepresented in the FR/SD group (69 vs. 38%; p = 0.03). No differences were found in terms of haematuria, hypoalbuminaemia, or days to achieve remission. In total, 31 and 23 patients were on a 6 + 6-week (pred-long) and 4 + 4-week (pred-short) steroid treatment regimen, respectively. There was a reduction in the number of FR/SD patients in the pred-long group relative to the pred-short group (38 vs. 80%, respectively). In the pred-long group, the 12 FR/SD patients were younger than the 19 non-FR/SD patients (4.4 +/- 3.1 vs. 8.4 +/- 4.1 years; p<0.005). Low age at debut and male gender was associated with a high risk of SD/FR in this unselected series of SSNS patients despite the prolongation of the steroid course at debut of SSNS.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.