ReviewThe AAPS journal2010
Deorphanization of novel peptides and their receptors.
Review in The AAPS journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Article
- Bioinformatics for Prohormone and Neuropeptide Discovery.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Bioactive Molecules from the Innate Immunity of Ascidians and Innovative Methods of Drug Discovery: A Computational Approach Based on Artificial Intelligence.Marine drugs · 2023Review
- AlphaFold2 enables accurate deorphanization of ligands to single-pass receptors.bioRxiv : the preprint server for biology · 2023Article
- Novel approaches leading towards peptide GPCR de-orphanisation.British journal of pharmacology · 2020Review
- Discovery of endogenous inverse agonists for G protein-coupled receptor 6.Biochemical and biophysical research communications · 2020Article
- Article
- Bioinformatics for Prohormone and Neuropeptide Discovery.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Carboxypeptidase E and the Identification of Novel Neuropeptides as Potential Therapeutic Targets.Advances in pharmacology (San Diego, Calif.) · 2018Review
- G Protein-Coupled Receptor (GPCR) Expression in Native Cells: "Novel" endoGPCRs as Physiologic Regulators and Therapeutic Targets.Molecular pharmacology · 2015Review
- Article
- A chemogenomics based approach for deorphanization of testicular receptor 4: An orphan receptor of nuclear receptor superfamily.Journal of natural science, biology, and medicine · 2013Review
- G protein-coupled receptor deorphanizations.Annual review of pharmacology and toxicology · 2013Review
- Orphan G protein-coupled receptors (GPCRs): biological functions and potential drug targets.Acta pharmacologica Sinica · 2012Review
- Molecular Imaging and Contrast Agent Database (MICAD): evolution and progress.Molecular imaging and biology · 2012Review
- DNA display selection of peptide ligands for a full-length human G protein-coupled receptor on CHO-K1 cells.PloS one · 2012Article
- Investigating endogenous peptides and peptidases using peptidomics.Biochemistry · 2011Review
- Novel neuropeptides as ligands of orphan G protein-coupled receptors.Current pharmaceutical design · 2011Review
- Fishing for the hidden peptidome in health and disease (drug abuse).The AAPS journal · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Peptide hormones and neuropeptides play important roles in endocrine and neural signaling, often using G protein-coupled receptor (GPCR)-mediated signaling pathways. However, the rate of novel peptide discovery has slowed dramatically in recent years. Genomic sequencing efforts have yielded a large number of cDNA sequences that potentially encode novel candidate peptide precursors, as well as hundreds of orphan GPCRs with no known cognate ligands. The complexity of peptide signaling is further highlighted by the requirement for specific posttranslational processing steps, and these must be accomplished in vitro prior to testing newly discovered peptide precursor candidates in receptor assays. In this review, we present historic as well as current approaches to peptide discovery and GPCR deorphanization. We conclude that parallel and combinatorial discovery methods are likely to represent the most fruitful avenues for both peptide discovery as well as for matching the remaining GPCRs with their peptide ligands.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.