ArticleCurrent atherosclerosis reports2010
Novel genetic mechanisms for aortic aneurysms.
Article in Current atherosclerosis reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 35 citations in OpenAlex.
- Regulation of PDE5 expression in human aorta and thoracic aortic aneurysms.Scientific reports · 2019Trial
- Genetic and Epigenetic Mechanisms Underlying Vascular Smooth Muscle Cell Phenotypic Modulation in Abdominal Aortic Aneurysm.International journal of molecular sciences · 2020Review
- Cellular Mechanisms of Aortic Aneurysm Formation.Circulation research · 2019Review
- Shared Genetic Risk Factors of Intracranial, Abdominal, and Thoracic Aneurysms.Journal of the American Heart Association · 2016Article
- Acute phase of aortic dissection: a pilot study on CD40L, MPO, and MMP-1, -2, 9 and TIMP-1 circulating levels in elderly patients.Immunity & ageing : I & A · 2016Article
- Understanding the pathogenesis of abdominal aortic aneurysms.Expert review of cardiovascular therapy · 2015Review
- Molecular basis and genetic predisposition to intracranial aneurysm.Annals of medicine · 2014Review
- Biglycan deficiency: increased aortic aneurysm formation and lack of atheroprotection.Journal of molecular and cellular cardiology · 2014Article
- Review
- A balanced translocation truncates Neurotrimin in a family with intracranial and thoracic aortic aneurysm.Journal of medical genetics · 2012Article
- Transient exposure of neonatal female mice to testosterone abrogates the sexual dimorphism of abdominal aortic aneurysms.Circulation research · 2012Article
- Regional expression of HOXA4 along the aorta and its potential role in human abdominal aortic aneurysms.BMC physiology · 2011Article
- Genes and abdominal aortic aneurysm.Annals of vascular surgery · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Aortic aneurysms occur in the thoracic and abdominal sections of the aorta and are a deadly late-age-at-onset disease with complex pathobiology. Currently, the number of published genome-wide analyses including microarray-based expression profiling, DNA linkage studies, and genetic association studies is still limited and it is difficult to make generalizations about the disease pathogenesis or genetic risk factors contributing to aortic aneurysms, but it appears that thoracic aortic aneurysms differ in many ways from abdominal aortic aneurysms. Characterization of diseases at the molecular level is likely to lead to more accurate diagnoses and the use of "genomic nosology" of disease. The biggest future challenge will be to translate the genomic information to the clinic and improve our understanding of the disease processes, help us to develop better diagnostic tools, and lead to the design of new ways to manage aortic aneurysms in the era of personalized medicine.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.