Evidence map›Paper›PMID 20446015›Full record

ReviewCellular and molecular life sciences : CMLS2010

Post-transcriptional global regulation by CsrA in bacteria.

Johan Timmermans, Laurence Van Melderen

Open access · greenAbstract readReview
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 175 citations in OpenAlex.

  1. Article
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  4. Review
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  8. Sugar Import SuppressesbioRxiv : the preprint server for biology · 2025
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  12. Control ofmBio · 2025
    Article
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  20. Article

38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Johan TimmermansLaboratoire de Génétique et Physiologie Bactérienne, Institut de Biologie et de Médecine Moléculaires, Faculté des Sciences, Université Libre de Bruxelles, 12 rue des Professeurs Jeener et Brachet, 6041, Gosselies, Belgium.
Laurence Van Melderen
Université Libre de Bruxelles · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Global regulation allows bacteria to rapidly modulate the expression of a large variety of unrelated genes in response to environmental changes. Global regulators act at different levels of gene expression. This review focuses on CsrA, a post-transcriptional regulator that affects translation of its gene targets by binding mRNAs. CsrA controls a large variety of physiological processes such as central carbon metabolism, motility and biofilm formation. The activity of CsrA is itself tightly regulated by the CsrB and CsrC small RNAs and the BarA-UvrY two-component system.

Indexed as

Models, BiologicalAmino Acid SequenceBiofilmsCarbonEscherichia coli ProteinsGene Expression Regulation, BacterialMembrane ProteinsMolecular Sequence DataPhosphotransferasesRepressor ProteinsRNA-Binding ProteinsRNA, MessengerRNA, Small NuclearTranscription FactorsbarA protein, E coliCarbonCsrA protein, E coliEscherichia coli ProteinsMembrane ProteinsPhosphotransferasesRepressor ProteinsRNA-Binding ProteinsRNA, MessengerRNA, Small NuclearTranscription FactorsUvrY protein, E coli

Identifiers

PMID20446015
PMCPMC11115721
OpenAlexW2042065648

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.