ReviewMedical microbiology and immunology2010
Chlamydia pneumoniae infection and Alzheimer's disease: a connection to remember?
Review in Medical microbiology and immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Common Bacterial Infections and Risk of Dementia or Cognitive Decline: A Systematic Review.Journal of Alzheimer's disease : JAD · 2020Pooled it
- Association between Toxoplasma gondii seropositivity and Alzheimer's disease: a case-control study.Parasitology research · 2026Article
- Possible link betweenAfrican health sciences · 2025Article
- Repurposing doxycycline for Alzheimer's treatment: Challenges from a nano-based drug delivery perspective.Brain, behavior, & immunity - health · 2024Article
- mFrontiers in cell and developmental biology · 2024Review
- Alzheimer's disease and infectious agents: a comprehensive review of pathogenic mechanisms and microRNA roles.Frontiers in neuroscience · 2024Review
- Oh my gut! Is the microbial origin of neurodegenerative diseases real?Infection and immunity · 2023Review
- Genome Dynamics and Temperature Adaptation During Experimental Evolution of Obligate Intracellular Bacteria.Genome biology and evolution · 2023Article
- Does Dementia Have a Microbial Cause?NeuroSci · 2022Review
- The Role of Chronic Infection in Alzheimer's Disease: Instigators, Co-conspirators, or Bystanders?Current clinical microbiology reports · 2021Article
- Review
- Virulent Pseudomonas aeruginosa infection converts antimicrobial amyloids into cytotoxic prions.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Pathophysiological Mechanisms of Cognitive Impairment and Neurodegeneration byBrain sciences · 2020Review
- Amyloid beta peptide-degrading microbial enzymes and its implication in drug design.3 Biotech · 2020Review
- Burkholderia pseudomallei invades the olfactory nerve and bulb after epithelial injury in mice and causes the formation of multinucleated giant glial cells in vitro.PLoS neglected tropical diseases · 2020Article
- Borrelia burgdorferi as a risk factor for Alzheimer's dementia and mild cognitive impairment.European geriatric medicine · 2019Article
- The Possibility of an Infectious Etiology of Alzheimer Disease.Molecular neurobiology · 2019Review
- Binding of Elementary Bodies by the Opportunistic Fungal PathogenFrontiers in microbiology · 2018Article
- Bacterial infections among patients with psychiatric disorders: Relation with hospital stay, age, and psychiatric diagnoses.PloS one · 2018Article
- The Infectious Etiology of Alzheimer's Disease.Current neuropharmacology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD) is the most common cause of dementia in the elderly, whereby it is customary to distinguish between early familial FAD and late-onset AD (LOAD). The development of LOAD, the most prevalent form of AD, is believed to be a multifactorial process that may also involve infections with bacterial or viral pathogens. After the first report on the presence of Chlamydia pneumoniae (Cpn) in brains of patients with AD appeared in 1998, this bacterium has most often been implicated in AD pathogenesis. However, while some studies demonstrate a clear association between Cpn infection and AD, others have failed to confirm these findings. This might be due to heterogeneity of the specimens analyzed and lack of standardized detection methods. Additionally, non-availability of suitable chlamydial infection models severely hampers research in the field. In this review, we will critically discuss the possible role of Cpn in the pathogenesis of LOAD in light of the available data. We will also present three mutually non-exclusive hypotheses how Cpn might contribute to the pathogenesis of AD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.