Evidence map›Paper›PMID 20445744›Full record

ReviewJournal of biomedicine & biotechnology2010

What we know and do not know about sex and cardiac disease.

John P Konhilas

Open access · hybridAbstract readReview
In one paragraph

Review in Journal of biomedicine & biotechnology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Sex-Steroid Signaling in Lung Diseases and Inflammation.Advances in experimental medicine and biology · 2021
    Article
  3. Review
  4. Article
  5. Article
  6. Sex differences in exercise-induced cardiac hypertrophy.Pflugers Archiv : European journal of physiology · 2013
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

John P KonhilasDepartment of Physiology, Molecular Cardiovascular Research Program, Sarver Heart Center, University of Arizona, 1656 E Mabel, Medical Research Building, Room 320, Tucson, AZ 85724, USA. konhilas@arizona.edu
University of Arizona · US

Funding

Impact of AMP-activated kinase on sex differences in hypertrophic cardiomyopathyR01HL098256 · NHLBI · UNIVERSITY OF ARIZONA · PI KONHILAS, JOHN P · 2010 to 2014
$1.9M
Metabolism, Skeletal Muscle, Cardiac Disease, ExerciseK01AR052840 · NIAMS · UNIVERSITY OF COLORADO · PI KONHILAS, JOHN P · 2006 to 2010
$600k
NHLBI NIH HHS R01 HL098256NIAMS NIH HHS K01 AR052840
6 · The paper itself

Abstract

Cardiovascular disease (CVD) remains the single leading cause of death in both men and women. A large proportion of the population with CVD will die with a diagnosis of congestive heart failure (CHF). It is becoming increasingly recognized that sex differences exist in the etiology, development, and outcome of CHF. For example, compared to male counterparts, women that present with CHF are typically older and have systolic cardiac function that is not impaired. Despite a growing body of literature addressing the underlying mechanisms of sex dimorphisms in cardiac disease, there remain significant inconsistencies reported in these studies. Given that the development of CHF results from the complex integration of genetic and nongenetic cues, it is not surprising that the elucidation and subsequent identification of molecular mechanisms remains unclear. In this review, key aspects of sex differences in CVD and CHF will be highlighted with an emphasis on some of the unanswered questions regarding these differences. The contention is presented that it becomes critical to reference cellular mechanisms within the context of each sex to better understand these sex dimorphisms.

Indexed as

Heart DiseasesAnimalsFemaleHeartHumansMaleSex Factors

Identifiers

PMID20445744
PMCPMC2860154
OpenAlexW2032306546

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.