ArticleCirculation. Cardiovascular genetics2010
Differences in albuminuria between Hispanics and whites: an evaluation by genetic ancestry and country of origin: the multi-ethnic study of atherosclerosis.
Article in Circulation. Cardiovascular genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Population structure of Hispanics in the United States: the multi-ethnic study of atherosclerosis.PLoS genetics · 2012Pooled it
- Hispanic/Latino ethnic background and genetic ancestry in relation to atherosclerotic cardiovascular disease risk estimation: Findings from the Multi-Ethnic Study of Atherosclerosis (MESA).American journal of preventive cardiology · 2025Article
- Review
- Multimodal Identification of Molecular Factors Linked to Severe Diabetic Foot Ulcers Using Artificial Intelligence.International journal of molecular sciences · 2024Article
- Structural and social determinants of health: The multi-ethnic study of atherosclerosis.PloS one · 2024Article
- Skeletal Microstructure in Caribbean Hispanic Women.JBMR plus · 2023Article
- Racial/ethnic differences in eligibility for asthma biologics among pediatric populations.The Journal of allergy and clinical immunology · 2021Article
- CKD and ESRD in US Hispanics.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2019Review
- Sleep-Disordered Breathing and Prevalent Albuminuria in Hispanics/Latinos.Kidney international reports · 2018Article
- Admixture Mapping Identifies an Amerindian Ancestry Locus Associated with Albuminuria in Hispanics in the United States.Journal of the American Society of Nephrology : JASN · 2017Article
- African Ancestry-Specific Alleles and Kidney Disease Risk in Hispanics/Latinos.Journal of the American Society of Nephrology : JASN · 2017Article
- Association of sleep duration with kidney function and albuminuria: NHANES 2009-2012.Sleep health · 2016Article
- Effect of Genetic African Ancestry on eGFR and Kidney Disease.Journal of the American Society of Nephrology : JASN · 2015Article
- Association of serum lipids with outcomes in Hispanic hemodialysis patients of the West versus East Coasts of the United States.American journal of nephrology · 2015Article
- A Family History of Diabetes Modifies the Association between Elevated Urine Albumin Concentration and Hyperglycemia in Nondiabetic Mexican Adolescents.Journal of diabetes research · 2015Article
- Bone density, microarchitecture and stiffness in Caucasian and Caribbean Hispanic postmenopausal American women.Bone research · 2014Article
- Prevalence and type of BRCA mutations in Hispanics undergoing genetic cancer risk assessment in the southwestern United States: a report from the Clinical Cancer Genetics Community Research Network.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2013Article
- Estimating ancestral proportions in a multi-ethnic US sample: implications for studies of admixed populations.Human genomics · 2012Article
- Genetic admixture is associated with plasma hemostatic factor levels in self-identified African Americans and Hispanics: the Multi-Ethnic Study of Atherosclerosis.Journal of thrombosis and haemostasis : JTH · 2012Article
- Hispanic ethnicity and vascular access use in patients initiating hemodialysis in the United States.Clinical journal of the American Society of Nephrology : CJASN · 2012Article
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundReports show higher prevalence of albuminuria among Hispanics compared with whites. Differences by country of origin or genetic background are unknown. METHODS AND
resultsIn Multi-Ethnic Study of Atherosclerosis, we studied the associations of both genetic ancestry and country of origin with albumin to creatinine ratio among 1417 Hispanic versus white participants using multivariable linear regression and back transforming beta coefficients into relative difference (%RD, 95% CI). Percentage European, Native American, and African ancestry components for Hispanics were estimated using genetic admixture analysis. The proportions of European, Native American, and African genetic ancestry differed significantly by country of origin (P<0.0001); Mexican/Central Americans had the highest Native American (41+/-13%), Puerto Ricans had the highest European (61+/-15%), and Dominicans had the highest African (39+/-21%) ancestry. Hispanic ethnicity was associated with higher albumin/creatinine ratio compared with whites, but the association varied with the country of origin (adjusted P interaction=0.04). Mexican/Central Americans and Dominicans had higher albumin/creatinine ratio compared with whites after adjustment (RD 19%, 2% to 40% and RD 27%, 1% to 61%), but not Puerto Ricans (RD 8%, -12% to 34%). Higher Native American ancestry was associated with higher albuminuria after age and sex adjustment among all Hispanics (RD 11%, 1% to 21%) but was attenuated after further adjustment. Higher European ancestry was independently associated with lower albumin/creatinine ratio among Puerto Ricans (-21%, -34% to -6%) but not among Mexican/Central Americans and Dominicans.
conclusionsHispanics are a heterogeneous group with varying genetic ancestry. Risks of albuminuria differ across the country of origin groups. These differences may be due, in part, to differences in genetic ancestral components.
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