ArticleInvestigative ophthalmology & visual science2010
Task-dependent V1 responses in human retinitis pigmentosa.
Article in Investigative ophthalmology & visual science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 62 citations in OpenAlex.
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- Laminar functional magnetic resonance imaging in vision research.Frontiers in neuroscience · 2022Review
- Assessing functional reorganization in visual cortex with simulated retinal lesions.Brain structure & function · 2021Article
- Visuo-Acoustic Stimulation's Role in Synaptic Plasticity: A Review of the Literature.International journal of molecular sciences · 2021Review
- Functional Dynamics of Deafferented Early Visual Cortex in Glaucoma.Frontiers in neuroscience · 2021Article
- Mapping Visual Field Defects With fMRI - Impact of Approach and Experimental Conditions.Frontiers in neuroscience · 2021Article
- Validating Linear Systems Analysis for Laminar fMRI: Temporal Additivity for Stimulus Duration Manipulations.Brain topography · 2021Article
- Linear systems analysis for laminar fMRI: Evaluating BOLD amplitude scaling for luminance contrast manipulations.Scientific reports · 2020Article
- Cerebral Modifications and Visual Pathway Reorganization in Maculopathy: A Systematic Review.Frontiers in neuroscience · 2020Review
- Residual Visual Responses in Patients With Retinitis Pigmentosa Revealed by Functional Magnetic Resonance Imaging.Translational vision science & technology · 2019Article
- Sensitive Period for Cognitive Repurposing of Human Visual Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Enhanced Visual Attentional Modulation in Patients with Inherited Peripheral Retinal Degeneration in the Absence of Cortical Degeneration.Neural plasticity · 2019Article
- Comparing Clinical Perimetry and Population Receptive Field Measures in Patients with Choroideremia.Investigative ophthalmology & visual science · 2018Article
- Learning to see again: biological constraints on cortical plasticity and the implications for sight restoration technologies.Journal of neural engineering · 2017Review
- Reorganization of early visual cortex functional connectivity following selective peripheral and central visual loss.Scientific reports · 2017Article
- Primary visual cortical remapping in patients with inherited peripheral retinal degeneration.NeuroImage. Clinical · 2017Article
- Probing Human Visual Deficits with Functional Magnetic Resonance Imaging.Annual review of vision science · 2016Review
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 3 countries.
Funding
Abstract
purposeDuring measurement with functional MRI (fMRI) during passive viewing, subjects with macular degeneration (MD) have a large unresponsive lesion projection zone (LPZ) in V1. fMRI responses can be evoked from the LPZ when subjects engage in a stimulus-related task. The authors report fMRI measurements on a different class of subjects, those with retinitis pigmentosa (RP), who have intact foveal vision but peripheral visual field loss.
methodsThe authors measured three RP subjects and two control subjects. fMRI was performed while the subjects viewed drifting contrast pattern stimuli. The subjects passively viewed the stimuli or performed a stimulus-related task.
resultsDuring passive viewing, the BOLD response in the posterior calcarine cortex of all RP subjects was in phase with the stimulus. A bordering, anterior LPZ could be identified by responses that were in opposite phase to the stimulus. When the RP subjects made stimulus-related judgments, however, the LPZ responses changed: the responses modulated in phase with the stimulus and task. In control subjects, the responses in a simulated V1 LPZ were unchanged between the passive and the stimulus-related judgment conditions.
conclusionsTask-dependent LPZ responses are present in RP subjects, similar to responses measured in MD subjects. The results are consistent with the hypothesis that deleting the retinal input to the LPZ unmasks preexisting extrastriate feedback signals that are present across V1. The authors discuss the implications of this hypothesis for visual therapy designed to replace the missing V1 LPZ inputs and to restore vision.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.