ArticleProceedings of the National Academy of Sciences of the United States of America2010
Colloquium paper: how grandmother effects plus individual variation in frailty shape fertility and mortality: guidance from human-chimpanzee comparisons.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 72 citations in OpenAlex.
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- Comparative physiological anthropogeny: exploring molecular underpinnings of distinctly human phenotypes.Physiological reviews · 2023Review
- Life history impacts on infancy and the evolution of human social cognition.Frontiers in psychology · 2023Article
- Evolution of Human-Specific Alleles Protecting Cognitive Function of Grandmothers.Molecular biology and evolution · 2022Article
- Ongoing selection for a uniquely human null allele ofFASEB bioAdvances · 2021Article
- Demographic uniformitarianism: the theoretical basis of prehistoric demographic research and its cross-disciplinary challenges.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Women who breastfeed exhibit cognitive benefits after age 50.Evolution, medicine, and public health · 2021Article
- 'Evolutionary medicine' perspectives on Alzheimer's Disease: Review and new directions.Ageing research reviews · 2018Review
- Spontaneous Reproductive Tract Lesions in Aged Captive Chimpanzees.Veterinary pathology · 2016Article
- Unified theory of Alzheimer's disease (UTAD): implications for prevention and curative therapy.Journal of molecular psychiatry · 2016Review
- Reproductive History and Later-Life Comorbidity Trajectories: A Medicare-Linked Cohort Study From the Utah Population Database.Demography · 2015Article
- The multiple facets of Peto's paradox: a life-history model for the evolution of cancer suppression.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- On the apparent rarity of epithelial cancers in captive chimpanzees.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Inclusive fitness and differential productivity across the life course determine intergenerational transfers in a small-scale human society.Proceedings. Biological sciences · 2015Article
- Age-related decline in ovarian follicle stocks differ between chimpanzees (Pan troglodytes) and humans.Age (Dordrecht, Netherlands) · 2015Article
- Hugh's book and Krogh's animals: biodiversity and textbook examples in teaching.Advances in physiology education · 2014Article
- Response to Jablonski and Chaplin.Proceedings. Biological sciences · 2014Article
- Exercise, APOE genotype, and the evolution of the human lifespan.Trends in neurosciences · 2014Review
- Was skin cancer a selective force for black pigmentation in early hominin evolution?Proceedings. Biological sciences · 2014Review
- Brief communication: Adrenal androgens and aging: Female chimpanzees (Pan troglodytes) compared with women.American journal of physical anthropology · 2013Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the first paper to present formal theory explaining that senescence is a consequence of natural selection, W. D. Hamilton concluded that human postmenopausal longevity results from the contributions of ancestral grandmothers to the reproduction of their relatives. A grandmother hypothesis, subsequently elaborated with additional lines of evidence, helps explain both exceptional longevity and additional features of life history that distinguish humans from the other great apes. However, some of the variation observed in aging rates seems inconsistent with the tradeoffs between current and future reproduction identified by theory. In humans and chimpanzees, our nearest living relatives, individuals who bear offspring at faster rates do not cease bearing sooner. They continue to be fertile longer instead. Furthermore, within both species, groups with lower overall mortality rates have faster rates of increase in death risk with advancing age. These apparent contradictions to the expected life history tradeoffs likely result from heterogeneity in frailty among individuals. Whereas robust and frail alike must allocate investments between current and future reproduction, the more robust can afford more of both. This heterogeneity, combined with evolutionary tradeoffs and the key role of ancestral grandmothers they identify, helps explain aspects of human aging that increasingly concern us all.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.