ReviewMolecular & cellular proteomics : MCP2010
Profiling of protein interaction networks of protein complexes using affinity purification and quantitative mass spectrometry.
Review in Molecular & cellular proteomics : MCP, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
45 citing papers in PubMed.
- Recombinant Proteins: A Molecular Tool to Understand Marine Adhesion and to Advance Biomaterials.Advanced healthcare materials · 2026Review
- Enhancing cross-domain protein and peptide interaction with retrained deep learning models.Briefings in bioinformatics · 2025Article
- Crosslinking-mediated Interactome Analysis Identified PHD2-HIF1α Interaction Hotspots and the Role of PHD2 in Regulating Protein Neddylation.bioRxiv : the preprint server for biology · 2024Article
- Struct2Graph: a graph attention network for structure based predictions of protein-protein interactions.BMC bioinformatics · 2022Article
- Tunable heteroaromatic azoline thioethers (HATs) for cysteine profiling.Chemical science · 2022Article
- Proteome Composition of Bovine Amniotic Membrane and Its Potential Role in Corneal Healing.Investigative ophthalmology & visual science · 2021Article
- Development and Comparative Evaluation of Endolysosomal Proximity Labeling-Based Proteomic Methods in Human iPSC-Derived Neurons.Analytical chemistry · 2020Article
- Evolution of Sequence-based Bioinformatics Tools for Protein-protein Interaction Prediction.Current genomics · 2020Review
- Electron-deficient p-benzoyl-l-phenylalanine derivatives increase covalent chemical capture yields for protein-protein interactions.Protein science : a publication of the Protein Society · 2019Article
- Probing HMolecular & cellular proteomics : MCP · 2019Article
- Article
- Cross-Linking Mass Spectrometry: An Emerging Technology for Interactomics and Structural Biology.Analytical chemistry · 2018Review
- Dissecting Dynamic and Heterogeneous Proteasome Complexes Using In Vivo Cross-Linking-Assisted Affinity Purification and Mass Spectrometry.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Protein complex formation during denitrification by Pseudomonas aeruginosa.Microbial biotechnology · 2017Review
- A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress.JCI insight · 2017Article
- Protein Network of the Pseudomonas aeruginosa Denitrification Apparatus.Journal of bacteriology · 2016Article
- OncoBinder facilitates interpretation of proteomic interaction data by capturing coactivation pairs in cancer.Oncotarget · 2016Article
- Upregulation of GSK3β Contributes to Brain Disorders in Elderly REGγ-knockout Mice.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016Article
- Proteomics-Based Analysis of Protein Complexes in Pluripotent Stem Cells and Cancer Biology.International journal of molecular sciences · 2016Review
- Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth.Molecular & cellular proteomics : MCP · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Protein-protein interactions are important for nearly all biological processes, and it is known that aberrant protein-protein interactions can lead to human disease and cancer. Recent evidence has suggested that protein interaction interfaces describe a new class of attractive targets for drug development. Full characterization of protein interaction networks of protein complexes and their dynamics in response to various cellular cues will provide essential information for us to understand how protein complexes work together in cells to maintain cell viability and normal homeostasis. Affinity purification coupled with quantitative mass spectrometry has become the primary method for studying in vivo protein interactions of protein complexes and whole organism proteomes. Recent developments in sample preparation and affinity purification strategies allow the capture, identification, and quantification of protein interactions of protein complexes that are stable, dynamic, transient, and/or weak. Current efforts have mainly focused on generating reliable, reproducible, and high confidence protein interaction data sets for functional characterization. The availability of increasing amounts of information on protein interactions in eukaryotic systems and new bioinformatics tools allow functional analysis of quantitative protein interaction data to unravel the biological significance of the identified protein interactions. Existing studies in this area have laid a solid foundation toward generating a complete map of in vivo protein interaction networks of protein complexes in cells or tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.