ArticleEndocrinology2010
Deletion of androgen receptor in the smooth muscle of the seminal vesicles impairs secretory function and alters its responsiveness to exogenous testosterone and estradiol.
Article in Endocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 42 citations in OpenAlex.
- Does Heat-Induced Activation of Mast Cells Contribute to Elevated Temperature-Induced Male Infertility?Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Article
- Seminal vesicle protein caCA12 in Corydoras aeneus inhibits sperm motility for sperm drinking.The Journal of experimental biology · 2025Article
- Identification of Estrogen-Responsive Proteins in Mouse Seminal Vesicles Through Mass Spectrometry-Based Proteomics.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Article
- Crucial Roles of the Mesenchymal Androgen Receptor in Wolffian Duct Development.Endocrinology · 2023Article
- Prevention of seminal vesicle damage byPharmaceutical biology · 2023Article
- Functions of Steroid Hormones in the Male Reproductive Tract as Revealed by Mouse Models.International journal of molecular sciences · 2023Review
- Transcriptomic analysis of the seminal vesicle response to the reproductive toxicant acrylamide.BMC genomics · 2021Article
- A framework for high-resolution phenotyping of candidate male infertility mutants: from human to mouse.Human genetics · 2021Review
- Morphine andJournal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2020Article
- Ablation of the androgen receptor from vascular smooth muscle cells demonstrates a role for testosterone in vascular calcification.Scientific reports · 2016Article
- Autocrine androgen action is essential for Leydig cell maturation and function, and protects against late-onset Leydig cell apoptosis in both mice and men.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Peritubular myoid cells participate in male mouse spermatogonial stem cell maintenance.Endocrinology · 2014Article
- Androgen receptor (AR) physiological roles in male and female reproductive systems: lessons learned from AR-knockout mice lacking AR in selective cells.Biology of reproduction · 2013Review
- Spongian diterpenoids inhibit androgen receptor activity.Molecular cancer therapeutics · 2013Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
The seminal vesicles (SVs), like much of the male reproductive tract, depend on androgen-driven stromal-epithelial interactions for normal development, structure, and function. The primary function of the SVs is to synthesize proteins that contribute to the seminal plasma and this is androgen dependent. However, the cell-specific role for androgen action in adult SVs remains unclear. This study analyzed the SV in mice with targeted ablation of androgen receptors specifically in smooth muscle cells (PTM-ARKO) to determine in vivo whether it is androgen action in a subset of the SV stroma, the smooth muscle cells, that drives epithelial function and identity. These mice have significantly smaller SVs in adulthood with less smooth muscle and reduced epithelial cell height. Less epithelial cell proliferation was observed in adult PTM-ARKO SVs, compared with controls, and production of seminal proteins was reduced, indicating global impairment of epithelial cell function in PTM-ARKO SVs. None of these changes could be explained by altered serum testosterone or estradiol concentrations. We also demonstrate altered SV responsiveness to exogenous testosterone and estradiol in PTM-ARKO mice, indicating that smooth muscle androgen receptors may limit the SV epithelial proliferative response to exogenous estrogens. These results therefore demonstrate that the smooth muscle cells play a vital role in androgen-driven stromal-epithelial interactions in the SV, determining epithelial cell structure and function as well as limiting the SV epithelial proliferative response to exogenous estrogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.