ArticleThe Journal of clinical endocrinology and metabolism2010
Estrogen deficiency after menopause does not result in male very-low-density lipoprotein metabolism phenotype.
Article in The Journal of clinical endocrinology and metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Plasma lipid profiling of tissue-specific insulin resistance in human obesity.International journal of obesity (2005) · 2019Trial
- The regulation of intrahepatic fatty acid partitioning within the human liver: the effect of sex.Clinical science (London, England : 1979) · 2026Review
- Physiological interindividual variability in endogenous estradiol concentration does not influence adipose tissue and hepatic lipid kinetics in women.European journal of endocrinology · 2022Article
- Increased Adipose Tissue Indices of Androgen Catabolism and Aromatization in Women With Metabolic Dysfunction.The Journal of clinical endocrinology and metabolism · 2022Article
- Sexual dimorphism in cardiometabolic health: the role of adipose tissue, muscle and liver.Nature reviews. Endocrinology · 2021Review
- Different physiological mechanisms underlie an adverse cardiovascular disease risk profile in men and women.The Proceedings of the Nutrition Society · 2020Review
- Gender differences in LDL- and HDL-cholesterol subfractions in patients after the acute ischemic stroke and their association with oxidative stress markers.Journal of clinical biochemistry and nutrition · 2018Article
- The Sexual Dimorphism of Lipid Kinetics in Humans.Frontiers in endocrinology · 2015Review
- Testosterone increases the muscle protein synthesis rate but does not affect very-low-density lipoprotein metabolism in obese premenopausal women.American journal of physiology. Endocrinology and metabolism · 2012Article
- Obesity and altered glucose metabolism impact HDL composition in CETP transgenic mice: a role for ovarian hormones.Journal of lipid research · 2012Article
- Effects of aerobic exercise on urinary estrogens and progestagens in pre and postmenopausal women.European journal of applied physiology · 2012Article
- Sex differences in lipid and lipoprotein metabolism: it's not just about sex hormones.The Journal of clinical endocrinology and metabolism · 2011Review
- Antihyperlipidemic activity of chickpea sprouts supplementation in ovariectomy-induced dyslipidemia in rats.Journal of Ayurveda and integrative medicineArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
Abstract
contextSex differences in lipid metabolism result in a less proatherogenic plasma lipid profile in premenopausal women than men. The mechanisms responsible for this are unclear but are thought to be related to differences in the sex hormone milieu in men and women.
objectiveOur objective was to evaluate the effect of endogenous sex hormones on very-low-density lipoprotein (VLDL) triglyceride (TG) and apolipoprotein B-100 (apoB-100) metabolism. EXPERIMENTAL DESIGN AND
main outcome measuresWe measured basal VLDL-TG and VLDL-apoB-100 concentrations and kinetics by using stable isotope-labeled tracers. SETTING AND
participantsEight premenopausal women [age, 43 + or - 8 yr; body mass index (BMI), 35 + or - 4 kg/m(2); mean + or - sd], eight postmenopausal women (age, 55 + or - 4 yr; BMI, 34 + or - 4 kg/m(2)), and eight men (age, 41 + or - 13 yr; BMI, 34 + or - 4 kg/m(2)) were studied at Washington University School of Medicine, St. Louis, MO.
resultsVLDL-TG secretion rate was approximately double (P < 0.05) in postmenopausal women and men compared with premenopausal women but not different in postmenopausal women and men. The secretion rate of VLDL-apoB-100 was not different in pre- and postmenopausal women but was greater (P < 0.05) in men than in women.
conclusionsEndogenous ovarian sex steroids are responsible for sexual dimorphism in VLDL-TG secretion, whereas VLDL-apoB-100 secretion is not regulated by female reproductive hormones.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.