ArticleBiology letters2010
Disease association mapping in Drosophila can be replicated in the wild.
Article in Biology letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Applying genetic technologies to combat infectious diseases in aquaculture.Reviews in aquaculture · 2023Review
- Article
- High parasite diversity accelerates host adaptation and diversification.Science (New York, N.Y.) · 2018Article
- Review
- Review
- The Discovery, Distribution, and Evolution of Viruses Associated with Drosophila melanogaster.PLoS biology · 2015Article
- Viruses and antiviral immunity in Drosophila.Developmental and comparative immunology · 2014Review
- The genetics of infectious disease susceptibility: has the evidence for epistasis been overestimated?BMC biology · 2013Review
- Vertically transmitted viral endosymbionts of insects: do sigma viruses walk alone?Proceedings. Biological sciences · 2012Article
- Genome-wide association studies reveal a simple genetic basis of resistance to naturally coevolving viruses in Drosophila melanogaster.PLoS genetics · 2012Article
- Population genomics of wild and laboratory zebrafish (Danio rerio).Molecular ecology · 2011Article
- Successive increases in the resistance of Drosophila to viral infection through a transposon insertion followed by a Duplication.PLoS genetics · 2011Article
- The prevalence and persistence of sigma virus, a biparentally transmitted parasite ofEvolutionary ecology research · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Association and linkage mapping have become important tools in understanding the genetics of complex traits, including diseases in humans. As the success of association mapping is reduced by small effect sizes and limited power, linkage studies in laboratory-based model systems are still heavily used. But whether the results of these studies can be replicated in natural populations has been questioned. Here, we show that a polymorphism in the gene ref(2)P, which had previously been linked to sigma virus resistance in Drosophila melanogaster under laboratory conditions, also provides resistance against the virus in female flies in a wild population in the field. This genetic association is thus upheld in spite of a known genotype-by-genotype interaction and environmental variation.
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