Evidence map›Paper›PMID 20444698›Full record

ReviewThe Journal of biological chemistry2010

Molecular view of 43 S complex formation and start site selection in eukaryotic translation initiation.

Jon R Lorsch, Thomas E Dever

Abstract readReview
In one paragraph

Review in The Journal of biological chemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

  1. Trial
  2. Review
  3. Unconventional translation initiation factor EIF2A is required for Drosophila spermatogenesis.Developmental dynamics : an official publication of the American Association of Anatomists · 2022
    Article
  4. Identification of a Novel Heterozygous Mutation in theFrontiers in bioengineering and biotechnology · 2022
    Article
  5. Review
  6. Article
  7. Toward a Kinetic Understanding of Eukaryotic Translation.Cold Spring Harbor perspectives in biology · 2019
    Review
  8. Characterizing Cellular Responses During Oncolytic Maraba Virus Infection.International journal of molecular sciences · 2019
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. eIF4F: a retrospective.The Journal of biological chemistry · 2015
    Review
  16. Review
  17. Article
  18. Mechanism of cytoplasmic mRNA translation.The arabidopsis book · 2015
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jon R LorschDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. jlorsch@jhmi.edu
Thomas E Dever

Funding

Mechanism and Regulation of Eukaryotic Protein SynthesisZIAHD001010 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI DEVER, THOMAS E · 2009 to 2025
$29.4M
KINETIC DISSECTION OF EUKARYOTIC TRANSLATION INITIATIONR01GM062128 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 2000 to 2013
$4.6M
Intramural NIH HHSNIGMS NIH HHS GM62128NIGMS NIH HHS R01 GM062128
6 · The paper itself

Abstract

A central step to high fidelity protein synthesis is selection of the proper start codon. Recent structural, biochemical, and genetic analyses have provided molecular insights into the coordinated activities of the initiation factors in start codon selection. A molecular model is emerging in which start codon recognition is linked to dynamic reorganization of factors on the ribosome and structural changes in the ribosome itself.

Indexed as

Protein BiosynthesisCodon, InitiatorEukaryotic Initiation Factor-2Eukaryotic Translation Initiation Factor 5AHumansModels, BiologicalModels, GeneticMutationPeptide Chain Initiation, TranslationalPeptide Initiation FactorsPhenotypeProtein ConformationProtein Structure, TertiaryRibosomesRNA-Binding ProteinsCodon, InitiatorEukaryotic Initiation Factor-2Eukaryotic Translation Initiation Factor 5APeptide Initiation FactorsRNA-Binding Proteins

Identifiers

PMID20444698
PMCPMC2898419

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.