ReviewCurrent opinion in structural biology2010
Evolution: a guide to perturb protein function and networks.
Review in Current opinion in structural biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Design and characterization of a protein fold switching network.Nature communications · 2023Article
- Odd one out? Functional tuning of Zymomonas mobilis pyruvate kinase is narrower than its allosteric, human counterpart.Protein science : a publication of the Protein Society · 2022Article
- Review
- CAGI5: Objective performance assessments of predictions based on the Evolutionary Action equation.Human mutation · 2019Article
- Objective assessment of the evolutionary action equation for the fitness effect of missense mutations across CAGI-blinded contests.Human mutation · 2017Review
- The tumor suppressor capability of p53 is dependent on non-muscle myosin IIA function in head and neck cancer.Oncotarget · 2017Article
- Molecular cloning and biochemical characterization of two cation chloride cotransporter subfamily members of Hydra vulgaris.PloS one · 2017Article
- Genomic insights into head and neck cancer.Cancers of the head & neck · 2016Article
- Article
- Evolutionary Action Score of TP53 Identifies High-Risk Mutations Associated with Decreased Survival and Increased Distant Metastases in Head and Neck Cancer.Cancer research · 2015Article
- The functional importance of co-evolving residues in proteins.Cellular and molecular life sciences : CMLS · 2014Review
- Differential effects of collagen prolyl 3-hydroxylation on skeletal tissues.PLoS genetics · 2014Article
- Accounting for epistatic interactions improves the functional analysis of protein structures.Bioinformatics (Oxford, England) · 2013Article
- Are predicted protein structures of any value for binding site prediction and virtual ligand screening?Current opinion in structural biology · 2013Review
- Identification of amino acid residues responsible for the selectivity of tadalafil binding to two closely related phosphodiesterases, PDE5 and PDE6.The Journal of biological chemistry · 2012Article
- Sequence evolution of the intrinsically disordered and globular domains of a model viral oncoprotein.PloS one · 2012Article
- Separation of recombination and SOS response in Escherichia coli RecA suggests LexA interaction sites.PLoS genetics · 2011Article
- Protein function prediction: towards integration of similarity metrics.Current opinion in structural biology · 2011Review
- Article
- PyETV: a PyMOL evolutionary trace viewer to analyze functional site predictions in protein complexes.Bioinformatics (Oxford, England) · 2010Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Protein interactions give rise to networks that control cell fate in health and disease; selective means to probe these interactions are therefore of wide interest. We discuss here Evolutionary Tracing (ET), a comparative method to identify protein functional sites and to guide experiments that selectively block, recode, or mimic their amino acid determinants. These studies suggest, in principle, a scalable approach to perturb individual links in protein networks.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.