ArticleVirology2010
Dynamics and timing of in vivo mutations at Gag residue 242 during primary HIV-1 subtype C infection.
Article in Virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- No Difference in the Prevalence of HIV-1Vaccines · 2023Article
- Genome-wide association study reveals genetic variants associated with HIV-1C infection in a Botswana study population.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape.Nature structural & molecular biology · 2017Article
- Observational
- Analysis of Viral Diversity in Relation to the Recency of HIV-1C Infection in Botswana.PloS one · 2016Article
- Deciphering Multiplicity of HIV-1C Infection: Transmission of Closely Related Multiple Viral Lineages.PloS one · 2016Article
- A Generalized Entropy Measure of Within-Host Viral Diversity for Identifying Recent HIV-1 Infections.Medicine · 2015Article
- Host genetics and viral load in primary HIV-1 infection: clear evidence for gene by sex interactions.Human genetics · 2014Article
- Dynamics of viremia in primary HIV-1 infection in Africans: insights from analyses of host and viral correlates.Virology · 2014Article
- Article
- Intra-host evolutionary rates in HIV-1C env and gag during primary infection.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2013Article
- HLA-B*57 versus HLA-B*81 in HIV-1 infection: slow and steady wins the race?Journal of virology · 2013Article
- Impact of immune escape mutations on HIV-1 fitness in the context of the cognate transmitted/founder genome.Retrovirology · 2012Article
- Evolutionary gamut of in vivo Gag substitutions during early HIV-1 subtype C infection.Virology · 2011Article
- A Bayesian approach to analyse genetic variation within RNA viral populations.PLoS computational biology · 2011Article
- Transmission of single and multiple viral variants in primary HIV-1 subtype C infection.PloS one · 2011Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Viral mutations at Gag residue 242 and relevant viral polymorphisms were analyzed in a cohort of 42 individuals with primary HIV-1 subtype C infection using single-genome amplification/sequencing. In HLA-B*57/5801-negative subjects infected with 242N escape variant, reversion to Asn appeared at median (IQR) 103 days (97-213 days) post-seroconversion (p/s) and became dominant at 193 days (170-215 days) p/s. In subjects expressing HLA-B*57/5801 and infected with the wild-type virus, the T242N escape appeared at 203 days (196-231) p/s, reached dominance at 277 days (265-315 days) p/s, and became complete at 323 days (289-373 days) p/s. HLA-B*57/5801-negative subjects infected with 242N escape variant did not show reduced viral load or increased CD4 count. The study highlights the differential selection of T242N escape by HLA-B*57 and B*5801 and suggests that the presence of HLA-B*57/5801-mediated immune pressure is able to control replication of the wild-type virus encoding Thr at Gag residue 242 but fails to suppress the T242N escape variant.
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