ArticleAtherosclerosis2010
Association of Lp-PLA(2) activity with allele-specific Lp(a) levels in a bi-ethnic population.
Article in Atherosclerosis, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Associations between healthy food groups and platelet-activating factor, lipoprotein-associated phospholipase AEuropean journal of nutrition · 2024Article
- The association between dietary quality scores with C-reactive protein and novel biomarkers of inflammation platelet-activating factor and lipoprotein-associated phospholipase A2: a cross-sectional study.Nutrition & metabolism · 2023Article
- Independent association of Lp(a) with platelet reactivity in subjects without statins or antiplatelet agents.Scientific reports · 2022Article
- Lp(a) and SARS-CoV-2: A conspiracy of two mysteries.Journal of internal medicine · 2022Article
- Effect of antiretroviral therapy on allele-associated Lp(a) level in women with HIV in the Women's Interagency HIV Study.Journal of lipid research · 2018Article
- The roles of apo(a) size, phenotype, and dominance pattern in PCSK9-inhibition-induced reduction in Lp(a) with alirocumab.Journal of lipid research · 2017Article
- Lipoprotein(a) and HIV: Allele-Specific Apolipoprotein(a) Levels Predict Carotid Intima-Media Thickness in HIV-Infected Young Women in the Women's Interagency HIV Study.Arteriosclerosis, thrombosis, and vascular biology · 2017Article
- Lipoprotein (a): impact by ethnicity and environmental and medical conditions.Journal of lipid research · 2016Review
- Lipoprotein(a) and apolipoprotein(a) in polycystic ovary syndrome.Clinical endocrinology · 2016Article
- Significant associations between lipoprotein(a) and corrected apolipoprotein B-100 levels in African-Americans.Atherosclerosis · 2014Article
- HIV disease activity as a modulator of lipoprotein(a) and allele-specific apolipoprotein(a) levels.Arteriosclerosis, thrombosis, and vascular biology · 2013Article
- Apo E4 and lipoprotein-associated phospholipase A2 synergistically increase cardiovascular risk.Atherosclerosis · 2012Article
- Lipoprotein(a): genotype-phenotype relationship and impact on atherogenic risk.Metabolic syndrome and related disorders · 2011Review
- Differential associations of serum amyloid A and pentraxin-3 with allele-specific lipoprotein(a) levels in African Americans and Caucasians.Translational research : the journal of laboratory and clinical medicine · 2011Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectivesLipoprotein-associated phospholipase A(2) (Lp-PLA(2)) and lipoprotein(a) [Lp(a)] have been implicated as cardiovascular disease risk factors, and are differentially regulated across ethnicity. We investigated the association between Lp-PLA(2) activity and allele-specific apolipoprotein(a) [apo(a)] levels in a bi-ethnic population.
methodsLp-PLA(2) activity, Lp(a) and allele-specific apo(a) levels were determined in 224 African Americans and 336 Caucasians.
resultsLp-PLA(2) activity level was higher among Caucasians compared to African Americans (173 + or - 41 nmol/min/ml vs. 141 + or - 39 nmol/min/ml, P<0.001), and positively associated with Lp(a), total and LDL cholesterol, triglyceride, apolipoprotein B-100, and negatively with HDL cholesterol levels in both ethnic groups. The association between Lp-PLA(2) activity and Lp(a) was stronger among African Americans compared to Caucasians (R=0.238, beta(1)=3.48, vs. R=0.111, beta(1)=1.93, respectively). The Lp-PLA(2) activity level was significantly associated with allele-specific apo(a) levels for smaller (<26 K4 repeats) apo(a) sizes in both ethnic groups (P=0.015 for African Americans, P=0.038 for Caucasians). In contrast, for larger (>26 K4 repeats) apo(a) sizes, high Lp-PLA(2) activity levels were associated with higher allele-specific apo(a) levels in African Americans (P=0.009), but not in Caucasians.
conclusionThe association between Lp-PLA(2) activity and allele-specific apo(a) levels differs across African American-Caucasian ethnicity.
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