Trial reportCritical care (London, England)2010
Endotoxemia-induced inflammation and the effect on the human brain.
Trial report in Critical care (London, England), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00513110 (A Possible Therapeutic Role for Adenosine During Inflammation), which is not on this map. Cited by 42 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Possible Therapeutic Role for Adenosine During Inflammation
Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 84 citations in OpenAlex.
- Biomarkers in septic encephalopathy: a systematic review of clinical studies.Revista Brasileira de terapia intensiva · 2013Pooled it
- The Effects of Neuroinflammation Induced by Typhoid Vaccine on Resting and Task-Based Electroencephalography.Brain and behavior · 2025Trial
- Inflamed but not impulsive: Acute inflammatory cytokine response does not impact prepotent response inhibition.Journal of affective disorders · 2023Trial
- Trial
- Epigenetic metabolite lipid nanoparticles alleviate venous thrombosis via bone marrow reprogramming.Blood vessels, thrombosis & hemostasis · 2025Article
- Article
- Research progress on the interaction between multiple organ-brain axes and perioperative neurocognitive disorders: a narrative review.Frontiers in aging neuroscience · 2025Review
- Metabolic Endotoxemia: From the Gut to Neurodegeneration.International journal of molecular sciences · 2024Review
- The incidence and predictors of antibiotic-associated encephalopathy: a multicenter hospital-based study.Scientific reports · 2024Article
- Cognotoxemia: endotoxemia and gender predict changes in working memory performance in healthy adults.Frontiers in neuroscience · 2024Article
- Neurofilament light chains to assess sepsis-associated encephalopathy: Are we on the track toward clinical implementation?Critical care (London, England) · 2023Review
- Neurochemical effects of sepsis on the brain.Clinical science (London, England : 1979) · 2023Article
- Andrographolide Attenuates Inflammation Due to Intra-Abdominal Sepsis by Enhancing Bacterial Clearance in Mice.Journal of inflammation research · 2023Article
- Cerebral dysfunctions caused by sepsis during ageing.Nature reviews. Immunology · 2022Review
- Pitavastatin Ameliorates Lipopolysaccharide-Induced Blood-Brain Barrier Dysfunction.Biomedicines · 2021Article
- The Use of Electroencephalography in Patients with Sepsis: a Review of The Literature.Journal of translational internal medicine · 2021Review
- Glucocorticoids and the Brain after Critical Illness.Endocrinology · 2021Review
- Inhibition of PAD2 Improves Survival in a Mouse Model of Lethal LPS-Induced Endotoxic Shock.Inflammation · 2020Article
- The dynamic change of serum S100B levels from day 1 to day 3 is more associated with sepsis-associated encephalopathy.Scientific reports · 2020Article
- Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionEffects of systemic inflammation on cerebral function are not clear, as both inflammation-induced encephalopathy as well as stress-hormone mediated alertness have been described.
methodsExperimental endotoxemia (2 ng/kg Escherichia coli lipopolysaccharide [LPS]) was induced in 15 subjects, whereas 10 served as controls. Cytokines (TNF-alpha, IL-6, IL1-RA and IL-10), cortisol, brain specific proteins (BSP), electroencephalography (EEG) and cognitive function tests (CFTs) were determined.
resultsFollowing LPS infusion, circulating pro- and anti-inflammatory cytokines, and cortisol increased (P < 0.0001). BSP changes stayed within the normal range, in which neuron specific enolase (NSE) and S100-beta changed significantly. Except in one subject with a mild encephalopathic episode, without cognitive dysfunction, endotoxemia induced no clinically relevant EEG changes. Quantitative EEG analysis showed a higher state of alertness detected by changes in the central region, and peak frequency in the occipital region. Improved CFTs during endotoxemia was found to be due to a practice effect as CFTs improved to the same extent in the reference group. Cortisol significantly correlated with a higher state of alertness detected on the EEG. Increased IL-10 and the decreased NSE both correlated with improvement of working memory and with psychomotor speed capacity. No other significant correlations between cytokines, cortisol, EEG, CFT and BSP were found.
conclusionsShort-term systemic inflammation does not provoke or explain the occurrence of septic encephalopathy, but primarily results in an inflammation-mediated increase in cortisol and alertness.
trial registrationNCT00513110.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.