ReviewClinical and translational science2010
Immunoregulation in TB: observations and implications.
Review in Clinical and translational science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Reduced systemic and mycobacterial antigen-stimulated concentrations of IL-1β and IL-18 in tuberculous lymphadenitis.Cytokine · 2017Trial
- CD4 lymphocyte dynamics in Tanzanian pulmonary tuberculosis patients with and without HIV co-infection.BMC infectious diseases · 2012Trial
- Low-doseFrontiers in immunology · 2024Article
- An Unresolving Case of Pyomyositis: A Case Report.Malaysian orthopaedic journal · 2023Article
- Malaria and tuberculosis co-infection-a review.Oxford open immunology · 2023Review
- Low body mass index is associated with diminished plasma cytokines and chemokines in both active and latent tuberculosis.Frontiers in nutrition · 2023Article
- Enhanced Mycobacterial Antigen-Induced Pro-Inflammatory Cytokine Production in Lymph Node Tuberculosis.The American journal of tropical medicine and hygiene · 2019Article
- Helminth mediated modulation of the systemic and mycobacterial antigen - stimulated cytokine profiles in extra-pulmonary tuberculosis.PLoS neglected tropical diseases · 2019Article
- High body mass index is associated with heightened systemic and mycobacterial antigen - Specific pro-inflammatory cytokines in latent tuberculosis.Tuberculosis (Edinburgh, Scotland) · 2016Article
- Coexistent Malnutrition Is Associated with Perturbations in Systemic and Antigen-Specific Cytokine Responses in Latent Tuberculosis Infection.Clinical and vaccine immunology : CVI · 2016Article
- Coincident diabetes mellitus modulates Th1-, Th2-, and Th17-cell responses in latent tuberculosis in an IL-10- and TGF-β-dependent manner.European journal of immunology · 2016Article
- Modulation of pro- and anti-inflammatory cytokines in active and latent tuberculosis by coexistent Strongyloides stercoralis infection.Tuberculosis (Edinburgh, Scotland) · 2015Article
- Novel targeting of PEGylated liposomes for codelivery of TGF-β1 siRNA and four antitubercular drugs to human macrophages for the treatment of mycobacterial infection: a quantitative proteomic study.Drug design, development and therapy · 2015Article
- The use of Mycobacterium tuberculosis HspX and GlcB proteins to identify latent tuberculosis in rheumatoid arthritis patients.Memorias do Instituto Oswaldo Cruz · 2014Article
- Coincident pre-diabetes is associated with dysregulated cytokine responses in pulmonary tuberculosis.PloS one · 2014Article
- Importance of reciprocal balance of T cell immunity in Mycobacterium abscessus complex lung disease.PloS one · 2014Article
- Postexposure subunit vaccination against chronic enteric mycobacterial infection in a natural host.Infection and immunity · 2013Article
- IL-10 dependent suppression of type 1, type 2 and type 17 cytokines in active pulmonary tuberculosis.PloS one · 2013Article
- New biomarkers with relevance to leprosy diagnosis applicable in areas hyperendemic for leprosy.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regulation of the immune response during active tuberculosis (TB) has been partly deciphered. In pulmonary TB there is transient systemic immunosuppression due to overexpression of transforming growth factor beta and interleukin-10. This is superimposed on a primary T-cell defect. Locally there is intense inflammation (lung, pleural fluid) with overexpression of immunosuppressive factors (bronchoalveolar lavage) and extensive apoptosis. These observations suggest that immune therapies should be aimed at neutralizing the negative regulatory factors rather than accentuating an already intense immune response. Also a partially effective vaccine carries the potential risk of exacerbating disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.