ArticleClinical and translational science2008
ErbB2 induces Notch1 activity and function in breast cancer cells.
Article in Clinical and translational science, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- Research progress on RNA-binding proteins in breast cancer.Oncology letters · 2022Review
- Relationship between metabolic reprogramming and drug resistance in breast cancer.Frontiers in oncology · 2022Review
- Review
- Notch Signaling Pathway Expression in the Skin of Leprosy Patients: Association With Skin and Neural Damage.Frontiers in immunology · 2020Observational
- Cyclin D1 integrates G9a-mediated histone methylation.Oncogene · 2019Article
- Plac1 Is a Key Regulator of the Inflammatory Response and Immune Tolerance In Mammary Tumorigenesis.Scientific reports · 2018Article
- Pathobiological implications of the d16HER2 splice variant for stemness and aggressiveness of HER2-positive breast cancer.Oncogene · 2017Article
- v-Src Oncogene Induces Trop2 Proteolytic Activation via Cyclin D1.Cancer research · 2016Article
- Mammary glands exhibit molecular laterality and undergo left-right asymmetric ductal epithelial growth in MMTV-cNeu mice.Oncogene · 2015Article
- miR-146a promotes the initiation and progression of melanoma by activating Notch signaling.eLife · 2014Article
- Cell fate factor DACH1 represses YB-1-mediated oncogenic transcription and translation.Cancer research · 2014Article
- Cyclin D1 determines estrogen signaling in the mammary gland in vivo.Molecular endocrinology (Baltimore, Md.) · 2013Article
- Article
- Withaferin A causes activation of Notch2 and Notch4 in human breast cancer cells.Breast cancer research and treatment · 2012Article
- Notch2 activation by benzyl isothiocyanate impedes its inhibitory effect on breast cancer cell migration.Breast cancer research and treatment · 2012Article
- Breast cancer stem cells.The international journal of biochemistry & cell biology · 2012Review
- The role of breast cancer stem cells in metastasis and therapeutic implications.The American journal of pathology · 2011Review
- Cell fate determination factor Dachshund reprograms breast cancer stem cell function.The Journal of biological chemistry · 2011Article
- The canonical NF-kappaB pathway governs mammary tumorigenesis in transgenic mice and tumor stem cell expansion.Cancer research · 2010Article
- Musashi1 regulates breast tumor cell proliferation and is a prognostic indicator of poor survival.Molecular cancer · 2010Article
Corrections and comments
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Authors and funding
19 authors at 3 institutions in 1 country.
Funding
Abstract
The ErbB2 (Her2/neu epidermal growth receptor family) oncogene is overexpressed in 30% to 40% of human breast cancers. Cyclin D1 is the regulatory subunit of the holoenzyme that phosphorylates and inactivates the retinoblastoma (pRb) tumor suppressor and is an essential downstream target of ErbB2-induced tumor growth. Herein, we demonstrate that ErbB2 induces the activity of the Notch signaling pathway. ErbB2 induction of DNA synthesis, contact-independent growth, and mammosphere induction required Notch1. ErbB2-induced cyclin D1 and cyclin D1 expression was suficient to induce Notch1 activity, and conversely, genetic deletion of Notch1 in mammary epithelial cells using foxed Notch (Notch(fl/fl)) mice demonstrated that cyclin D1 is induced by Notch1. Genetic deletion of cyclin D1 or small interfering RNA (siRNA) to cyclin D1-reduced Notch1 activity and reintroduction of cyclin D1 into cyclin D1-deficient cells restored Notch1 activity through the inhibition of Numb, an endogenous inhibitor of Notch1 activity. Thus, cyclin D1 functions downstream as a genetic target of Notch1, amplifies Notch1 activity by repressing Numb, and identifies a novel pathway by which ErbB2 induces Notch1 activity via the induction of cyclin D1.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.