ArticleMammalian genome : official journal of the International Mammalian Genome Society2010
Mitochondrial polymorphisms in rat genetic models of hypertension.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Mitochondrial Dysfunction in Cardiac Diseases and Therapeutic Strategies.Biomedicines · 2023Review
- Conplastic strains for identification of retrograde effects of mitochondrial dna variation on cardiometabolic traits in the spontaneously hypertensive rat.Physiological research · 2021Review
- Vertical selection for nuclear and mitochondrial genomes shapes gut microbiota and modifies risks for complex diseases.Physiological genomics · 2020Article
- Whole genome sequencing and novel candidate genes for CAKUT and altered nephrogenesis in the HSRA rat.Physiological genomics · 2020Article
- Mitochondrial DNA mutations and cardiovascular disease.Current opinion in cardiology · 2017Article
- Endothelial Cell Bioenergetics and Mitochondrial DNA Damage Differ in Humans Having African or West Eurasian Maternal Ancestry.Circulation. Cardiovascular genetics · 2016Article
- Kidney-Specific Reduction of Oxidative Phosphorylation Genes Derived from Spontaneously Hypertensive Rat.PloS one · 2015Article
- Mitochondrial DNA association study of type 2 diabetes with or without ischemic stroke in Taiwan.BMC research notes · 2014Article
- Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overload.The Biochemical journal · 2013Article
- Renal angiotensin II type 1 receptor expression and associated hypertension in rats with minimal SHR nuclear genome.Physiological reports · 2013Article
- Primarily screening and analyzing ESTs differentially expressed in rats' primary liver cancer.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2013Article
- Construction of two novel reciprocal conplastic rat strains and characterization of cardiac mitochondria.American journal of physiology. Heart and circulatory physiology · 2013Article
- Nonsynonymous variants in mt-Nd2, mt-Nd4, and mt-Nd5 are linked to effects on oxidative phosphorylation and insulin sensitivity in rat conplastic strains.Physiological genomics · 2012Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Hypertension is a complex trait that has been studied extensively for genetic contributions of the nuclear genome. We examined mitochondrial genomes of the hypertensive strains: the Dahl Salt-Sensitive (S) rat, the Spontaneously Hypertensive Rat (SHR), and the Albino Surgery (AS) rat, and the relatively normotensive strains: the Dahl Salt-Resistant (R) rat, the Milan Normotensive Strain (MNS), and the Lewis rat (LEW). These strains were used previously for linkage analysis for blood pressure (BP) in our laboratory. The results provide evidence to suggest that variations in the mitochondrial genome do not account for observed differences in blood pressure between the S and R rats. However, variants were detected among the mitochondrial genomes of the various hypertensive strains, S, SHR, and AS, and also among the normotensive strains R, MNS, and LEW. A total of 115, 114, 106, 106, and 16 variations in mtDNA were observed between the comparisons S versus LEW, S versus MNS, S versus SHR, S versus AS, and SHR versus AS, respectively. Among the 13 genes coding for proteins of the electron transport chain, 8 genes had nonsynonymous variations between S, LEW, MNS, SHR, and AS. The lack of any sequence variants between the mitochondrial genomes of S and R rats provides conclusive evidence that divergence in blood pressure between these two inbred strains is exclusively programmed through their nuclear genomes. The variations detected among the various hypertensive strains provides the basis to construct conplastic strains and further evaluate the effects of these variants on hypertension and associated phenotypes.
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