ArticleImmunogenetics2010
Organization of the variable region of the immunoglobulin heavy-chain gene locus of the rat.
Article in Immunogenetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- A primer set for the rapid isolation of scFv fragments against cell surface antigens from immunised rats.Scientific reports · 2020Article
- Genetic removal of the CH1 exon leads to the production of hypofunctional heavy chain-only IgG2a in rats.Transgenic research · 2020Article
- The formation of mutated IgM memory B cells in rat splenic marginal zones is an antigen dependent process.PloS one · 2019Article
- Heterogeneity of Memory Marginal Zone B Cells.Critical reviews in immunology · 2018Review
- Characterization of the torafugu (Takifugu rubripes) immunoglobulin heavy chain gene locus.Immunogenetics · 2015Article
- Immunoglobulin genomics in the guinea pig (Cavia porcellus).PloS one · 2012Article
- A preliminary analysis of the immunoglobulin genes in the African elephant (Loxodonta africana).PloS one · 2011Article
- Factors important in evolutionary shaping of immunoglobulin gene loci.Immunome research · 2010Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have mapped and annotated the variable region of the immunoglobulin heavy (IGH) gene locus of the Brown Norway (BN) rat (assembly V3.4; Rat Genomic Sequence Consortium). In addition to known variable region genes, we found 12 novel previously unidentified functional IGHV genes and 1 novel functional IGHD gene. In total, the variable region of the rat IGH locus is composed of at least 353 unique IGHV genes, 21 IGHD genes, and 5 IGHJ genes, of which 131, 14, and 4 are potentially functional genes, respectively. Of all species studied so far, the rat seems to have the highest number of functional IGHV genes in the genome. Rat IGHV genes can be classified into 13 IGHV families based on nucleotide sequence identity. The variable region of the BN rat spans a total length of approximately 4.9 Mb and is organized in a typical translocon organization. Like the mouse, members of the various IGHV gene families are more or less grouped together on the genome, albeit some members of IGHV gene families are found intermingled with each other. In the rat, the largest IGHV gene families are IGHV1, IGHV2, and IGHV5. The overall conclusion is that the genomic organization of the variable region of the rat IGH locus is strikingly similar to that of the mouse, illustrating the close evolutionary relationship between these two species.
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