Trial reportNeuroradiology2011
Postprocedural CT for perivertebral cement leakage in percutaneous vertebroplasty is not necessary--results from VERTOS II.
Trial report in Neuroradiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Risk factors for secondary fractures to percutaneous vertebroplasty for osteoporotic vertebral compression fractures: a systematic review.Journal of orthopaedic surgery and research · 2021Pooled it
- Pooled it
- Bone-filling mesh container versus percutaneous kyphoplasty in treating Kümmell's disease.Archives of osteoporosis · 2019Trial
- Analysis of related factors on the deformity correction of balloon kyphoplasty.AJNR. American journal of neuroradiology · 2014Trial
- Open cavotomy for retrieval of inferior vena cava cement embolism after cement-augmented spinal fusion.Journal of vascular surgery cases and innovative techniques · 2026Article
- Percutaneous Vertebroplasty and Balloon Kyphoplasty for Painful Osteoporotic Vertebral Compression Fractures: A Health Technology Assessment.Ontario health technology assessment series · 2025Article
- Risk of new vertebral compression fractures and serious adverse effects after vertebroplasty: a systematic, critical review and meta-analysis of randomized controlled trials.Quantitative imaging in medicine and surgery · 2024Article
- Deep learning-based multimodal image analysis predicts bone cement leakage during percutaneous kyphoplasty: protocol for model development, and validation by prospective and external datasets.Frontiers in medicine · 2024Article
- Complications of Percutaneous Vertebroplasty: A Pictorial Review.Medicina (Kaunas, Lithuania) · 2023Review
- [Effect of injury degree of osteoporotic vertebral compression fracture on bone cement cortical leakage after percutaneous kyphoplasty].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2023Article
- Vertebral augmentation reduces the 12-month mortality and morbidity in patients with osteoporotic vertebral compression fractures.European radiology · 2021Article
- Basivertebral foramina of true vertebrae: morphometry, topography and clinical considerations.Surgical and radiologic anatomy : SRA · 2021Article
- Risk factors for cement leakage and nomogram for predicting the intradiscal cement leakage after the vertebra augmented surgery.BMC musculoskeletal disorders · 2020Article
- Novel Surgical Strategy for Treating Osteoporotic Vertebral Fractures with Cord Compression.Orthopaedic surgery · 2019Article
- Pulmonary cement embolism following balloon kyphoplasty: The impact of a procedural complication in a new era for lung cancer management.Molecular and clinical oncology · 2019Article
- Cement leakage and complication of liposarcoma spinal metastasis during vertebral augmentation procedure: a case report.Journal of medical case reports · 2016Article
- Percutaneous Vertebroplasty: A New Serial Injection Technique to Minimize Cement Leak.Asian spine journal · 2015Article
- Minimally Invasive Technique for PMMA Augmentation of Fenestrated Screws.TheScientificWorldJournal · 2015Article
- The clinical comparative study on high and low viscosity bone cement application in vertebroplasty.International journal of clinical and experimental medicine · 2015Article
- Clinical outcome after the use of a new craniocaudal expandable implant for vertebral compression fracture treatment: one year results from a prospective multicentric study.BioMed research international · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDuring percutaneous vertebroplasty (PV), perivertebral cement leakage frequently occurs. There is some concern that cement deposits may migrate towards the lungs via the veins during follow-up. We used baseline and follow-up computed tomography (CT) to assess the incidence and extend of late cement migration in a large consecutive patient cohort.
methodsVERTOS II is a prospective multicenter randomized controlled trial comparing PV with conservative therapy for osteoporotic vertebral compression fractures (OVCFs). Patients assigned to PV had baseline postprocedural CT scans of the treated vertebral bodies. After a mean follow-up of 22 months, 54 of 78 patients (69%) had follow-up CT. CT scans were analyzed and compared for perivertebral venous, discal, and soft tissue leakage.
resultsPerivertebral cement leakage occurred in 64 of 80 treated vertebrae (80%; 95% CI, 70% to 87%). All patients remained asymptomatic. Perivertebral venous leakage was present in 56 vertebrae (88%), mostly in the anterior external venous plexus (46 of 56, 82%). Discal leakage occurred in 22 of 64 vertebrae (34%) and soft tissue leakage in two of 64 (4%). Mean injected cement volume in vertebrae with leakage was higher (4.5 versus 3.7 cm(3), p = 0.04). Follow-up CT scan showed unchanged perivertebral cement leakages without late cement migration.
conclusionPerivertebral cement leaks during PV for OVCFs occurred frequently in the VERTOS II trial. Cement leakage occurred more frequently with higher injected volumes. However, all patients remained asymptomatic, and late cement migration during follow-up did not occur. Standard postprocedural CT of the treated vertebral body in PV is not necessary.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.