ArticleMetabolomics : Official journal of the Metabolomic Society2009
Assessing individual metabolic responsiveness to a lipid challenge using a targeted metabolomic approach.
Article in Metabolomics : Official journal of the Metabolomic Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 64 citations in OpenAlex.
- Recreational football practice attenuates postprandial lipaemia in normal and overweight individuals.European journal of applied physiology · 2018Trial
- Effects of chemosignals from sad tears and postprandial plasma on appetite and food intake in humans.PloS one · 2012Trial
- Glycerophospholipids in ALS: insights into disease mechanisms and clinical implication.Molecular neurodegeneration · 2025Review
- Revealing static and dynamic biomarkers from postprandial metabolomics data through coupled matrix and tensor factorizations.Metabolomics : Official journal of the Metabolomic Society · 2024Article
- Characterizing human postprandial metabolic response using multiway data analysis.Metabolomics : Official journal of the Metabolomic Society · 2024Article
- Precision Nutrition and Cardiovascular Disease Risk Reduction: the Promise of High-Density Lipoproteins.Current atherosclerosis reports · 2023Review
- Dynamic patterns of postprandial metabolic responses to three dietary challenges.Frontiers in nutrition · 2022Article
- Advantages of Studying the Metabolome in Response to Mixed-Macronutrient Challenges and Suggestions for Future Research Designs.The Journal of nutrition · 2021Article
- Wearable Technology to Quantify the Nutritional Intake of Adults: Validation Study.JMIR mHealth and uHealth · 2020Article
- Article
- Plasma metabolomics reveals lower carnitine concentrations in overweight Labrador Retriever dogs.Acta veterinaria Scandinavica · 2019Article
- APOE and the Association of Fatty Acids With the Risk of Stroke, Coronary Heart Disease, and Mortality.Stroke · 2018Article
- Effects of stimulation technique, anatomical region, and time on human sweat lipid mediator profiles.Prostaglandins & other lipid mediators · 2018Article
- 21st century toolkit for optimizing population health through precision nutrition.Critical reviews in food science and nutrition · 2018Review
- Metabolomic profiles of plasma, exhaled breath condensate, and saliva are correlated with potential for air toxics detection.Journal of breath research · 2017Article
- Profiling the Oxylipin and Endocannabinoid Metabolome by UPLC-ESI-MS/MS in Human Plasma to Monitor Postprandial Inflammation.PloS one · 2015Article
- Metabolome and fecal microbiota in monozygotic twin pairs discordant for weight: a Big Mac challenge.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2014Article
- The future of yogurt: scientific and regulatory needs.The American journal of clinical nutrition · 2014Article
- A preliminary report on oral fat tolerance test in rhesus monkeys.Lipids in health and disease · 2014Article
- Nutritional lipidomics: molecular metabolism, analytics, and diagnostics.Molecular nutrition & food research · 2013Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The development of assessment techniques with immediate clinical applicability is a priority for resolving the growing epidemic in metabolic disease. Many imbalances in diet-dependent metabolism are not detectable in the fasted state. Resolving the high inter-individual variability in response to diet requires the development of techniques that can detect metabolic dysfunction at the level of the individual. The intra- and inter-individual variation in lipid metabolism in response to a standardized test meal was determined. Following an overnight fast on three different days, three healthy subjects consumed a test meal containing 40% of their daily calories. Plasma samples were collected at fasting, and 1, 3, 6, and 8 h after the test meal. Plasma fatty acid (FA) concentrations within separated lipid classes and lipoprotein fractions were measured at each time point. The intra-individual variation within each subject across three days was lower than the inter-individual differences among the three subjects for over 50% of metabolites in the triacylglycerol (TG), FA, and phosphatidylcholine (PC) lipid classes at 6 h, and for 25-50% of metabolites across lipid classes at 0, 1, 3, and 8 h. The consistency of response within individuals was visualized by principal component analysis (PCA) and confirmed by ANOVA. Three representative metabolites that discriminated among the three individuals in the apolipoprotein B (ApoB) fraction, TG16:1n7, TG18:2n6, and PC18:3n3, are discussed in detail. The postprandial responses of individuals were unique within metabolites that were individual discriminators (ID) of metabolic phenotype. This study shows that the targeted metabolomic measurement of individual metabolic phenotype in response to a specially formulated lipid challenge is possible even without lead-in periods, dietary and lifestyle control, or intervention over a 3-month period in healthy free-living individuals.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.