ArticlePediatric research2010
Extracorporeal membrane oxygenation causes loss of intestinal epithelial barrier in the newborn piglet.
Article in Pediatric research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 67 citations in OpenAlex.
- Hemoglobin binders reduce inflammation and tissue injury from hemolysis in venovenous extracorporeal circulation.Blood advances · 2026Article
- Deleterious Effects of Liberal Fluid Therapy During Extracorporeal Cardiopulmonary Resuscitation in a Porcine Model of Prolonged Cardiac Arrest.Journal of the American Heart Association · 2026Article
- Article
- Nutrition Provision in Children with Heart Disease on Extracorporeal Membrane Oxygenation (ECMO).Pediatric cardiology · 2025Article
- ECMO-associated nosocomial infections in adults: immunopathogenesis and predictive modeling approaches.Frontiers in medicine · 2025Review
- Dexamethasone alleviates acute lung injury in a rat model with venovenous extracorporeal membrane oxygenation support.BMJ open respiratory research · 2024Article
- Neutrophils: a key component in ECMO-related acute organ injury.Frontiers in immunology · 2024Review
- Fluid Management in Veno-Arterial Extracorporeal Membrane Oxygenation Therapy-Analysis of an Experimental Pig Model.Journal of clinical medicine · 2023Article
- Clinical effect of early enteral nutrition support on critically ill neonates with extracorporeal membrane oxygenation.BMC pediatrics · 2023Article
- Ischemia-induced intestinal de-epithelization and consequent cholangitis lenta after usage of extracorporeal membrane oxygenation in COVID-19 patients: an autopsy series.Oxford medical case reports · 2023Article
- The Disconnect Between Extracorporeal Circulation and the Microcirculation: A Review.ASAIO journal (American Society for Artificial Internal Organs : 1992) · 2022Review
- Mechanical Circulatory Support: Primer for Consultant Specialists.Clinical journal of the American Society of Nephrology : CJASN · 2022Review
- Incidence of Acute Kidney Injury Is Lower in High-Risk Patients Undergoing Percutaneous Coronary Intervention Supported with Impella Compared to ECMO.Journal of cardiovascular translational research · 2022Article
- Aptamer-based factor IXa inhibition preserves hemostasis and prevents thrombosis in a piglet model of ECMO.Molecular therapy. Nucleic acids · 2022Article
- Extracorporeal circulation impairs microcirculation perfusion and organ function.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Article
- Application of alpha1-antitrypsin in a rat model of veno-arterial extracorporeal membrane oxygenation.Scientific reports · 2021Article
- Impact of CRRT in Patients with PARDS Treated with VV-ECMO.Membranes · 2021Article
- Nutrition in Pediatric Extracorporeal Membrane Oxygenation: A Narrative Review.Frontiers in nutrition · 2021Review
- Evaluation of the Oxiris Membrane in Cardiogenic Shock Requiring Extracorporeal Membrane Oxygenation Support: Study Protocol for a Single Center, Single-Blind, Randomized Controlled Trial.Frontiers in cardiovascular medicine · 2021Article
- Endotoxin Activity in Patients With Extracorporeal Membrane Oxygenation Life Support: An Observational Pilot Study.Frontiers in medicine · 2021Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
Extracorporeal membrane oxygenation (ECMO) is an important life-support system used in neonates and young children with intractable cardiorespiratory failure. In this study, we used our porcine neonatal model of venoarterial ECMO to investigate whether ECMO causes gut barrier dysfunction. We subjected 3-wk-old previously healthy piglets to venoarterial ECMO for up to 8 h and evaluated gut mucosal permeability, bacterial translocation, plasma levels of bacterial products, and ultrastructural changes in gut epithelium. We also measured plasma lipopolysaccharide (LPS) levels in a small cohort of human neonates receiving ECMO. In our porcine model, ECMO caused a rapid increase in gut mucosal permeability within the first 2 h of treatment, leading to a 6- to 10-fold rise in circulating bacterial products. These changes in barrier function were associated with cytoskeletal condensation in epithelial cells, which was explained by phosphorylation of a myosin II regulatory light chain. In support of these findings, we also detected elevated plasma LPS levels in human neonates receiving ECMO, indicating a similar loss of gut barrier function in these infants. On the basis of these data, we conclude that ECMO is an independent cause of gut barrier dysfunction and bacterial translocation may be an important contributor to ECMO-related inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.