ArticleJAMA2010
Age-specific trends in incidence of noncardia gastric cancer in US adults.
Article in JAMA, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 235 papers, 6 of them syntheses that pooled it.
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Who cites it
235 citing papers in PubMed, 6 syntheses or guidelines pooled it, 465 citations in OpenAlex.
- Meta-Analysis Reveals the Prognostic Relevance of Nuclear and Membrane-Associated Bile Acid Receptors in Gastric Cancer.Clinical and translational gastroenterology · 2021Pooled it
- Six Autoimmune Disorders Are Associated With Increased Incidence of Gastric Cancer: A Systematic Review and Meta-Analysis of Half a Million Patients.Frontiers in immunology · 2021Pooled it
- Guideline
- Molecular-targeted first-line therapy for advanced gastric cancer.The Cochrane database of systematic reviews · 2016Pooled it
- Pooled it
- Long-term proton pump inhibitor (PPI) use and the development of gastric pre-malignant lesions.The Cochrane database of systematic reviews · 2014Pooled it
- Regional Arterial Infusion Chemotherapy improves the Pathological Response rate for advanced gastric cancer with Short-term Neoadjuvant Chemotherapy.Scientific reports · 2015Trial
- Post-Treatment Surveillance to Detect Recurrent Disease in Esophagogastric Cancer: A Review of Current Practice and Future Perspectives.Journal of clinical medicine · 2026Review
- Evolution of birth-cohort patterns in lifestyle-associated cancer mortality across high-income countries.International journal of epidemiology · 2026Article
- Early-Onset Gastric Cancer as a High-Risk Disease Entity in the United States: Clinicopathologic Features, Regional Variation, and Outcomes.Cancer medicine · 2026Article
- Article
- Stomach Cancer Incidence in Asians as Compared to Other Ethnic Populations Over Time from 2000 to 2021 in SEER Areas of the United States.Asian Pacific journal of cancer prevention : APJCP · 2025Article
- Short-term outcomes of minimally invasive gastrectomy in population with obesity versus population without obesity: the obesity paradox.Updates in surgery · 2025Article
- Global lifetime estimates of expected and preventable gastric cancers across 185 countries.Nature medicine · 2025Article
- A Longitudinal Study of Premalignant Gastric Lesions and Early Onset Gastric Cancer Among Young Adults in Central Saudi Arabia.Current oncology (Toronto, Ont.) · 2025Observational
- Birth Cohort Effects in Appendiceal Adenocarcinoma Incidence Across the United States.Annals of internal medicine · 2025Article
- Prevalence of HER2 expression and its association with clinicopathological parameters in gastric and gastroesophageal junction adenocarcinoma: A 10?year experience of an academic center.Molecular and clinical oncology · 2025Article
- Deciphering aging-associated prognosis and heterogeneity in gastric cancer through a machine learning-driven approach.iScience · 2025Article
- Novel and Effective Blood-Based miRNA Diagnostic Panel for Gastric Cancer: A Pilot Study in a Japanese Population.Cancer medicine · 2025Article
- Incidence Trends in Upper Gastrointestinal Cancer in Young Adults: A Nationwide Time-Trend Analysis Using 2001-2019 US Cancer Statistics Databases.The American journal of gastroenterology · 2025Article
175 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
contextFor the last 50 years, overall age-standardized incidence rates for noncardia gastric cancer have steadily declined in most populations. However, overall rates are summary measures that may obscure important age-specific trends.
objectiveTo examine effects of age at diagnosis on noncardia gastric cancer incidence trends in the United States. DESIGN, SETTING, AND
participantsDescriptive study with age-period-cohort analysis of cancer registration data from the National Cancer Institute's Surveillance, Epidemiology, and End Results Program, which covers approximately 26% of the US population. From 1977 through 2006, there were 83,225 adults with incident primary gastric cancer, including 39,003 noncardia cases.
main outcome measuresOverall and age-specific incidence rates, adjusted for period and cohort effects using age-period-cohort models. Results were stratified by race, sex, and socioeconomic status.
resultsOverall age-standardized annual incidence per 100,000 population declined during the study period from 5.9 (95% confidence interval [CI], 5.7-6.1) to 4.0 (95% CI, 3.9-4.1) in whites, from 13.7 (95% CI, 12.5-14.9) to 9.5 (95% CI, 9.1-10.0) in blacks, and from 17.8 (95% CI, 16.1-19.4) to 11.7 (95% CI, 11.2-12.1) in other races. Age-specific trends among whites varied significantly between older and younger age groups (P < .001 for interaction by age): incidence per 100,000 declined significantly from 19.8 (95% CI, 19.0-20.6) to 12.8 (95% CI, 12.5-13.1) for ages 60 to 84 years and from 2.6 (95% CI, 2.4-2.8) to 2.0 (95% CI, 1.9-2.1) for ages 40 to 59 years but increased significantly from 0.27 (95% CI, 0.19-0.35) to 0.45 (95% CI, 0.39-0.50) for ages 25 to 39 years. Conversely, rates for all age groups declined or were stable among blacks and other races. Age-period-cohort analysis confirmed a significant increase in whites among younger cohorts born since 1952 (P < .001).
conclusionsFrom 1977 through 2006, the incidence rate for noncardia gastric cancer declined among all race and age groups except for whites aged 25 to 39 years, for whom it increased. Additional surveillance and analytical studies are warranted to identify risk factors that may explain this unfavorable trend.
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