ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2010
Anisotropic regulation of Ankrd2 gene expression in skeletal muscle by mechanical stretch.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 34 citations in OpenAlex.
- The titin N2A-MARP signalosome constrains muscle longitudinal hypertrophy in response to stretch.eLife · 2026Article
- Transcriptomic Profiling of the Biceps Femoris Long Head 72 h Following a Football Match and Associations With Recovery Biomarkers.Scandinavian journal of medicine & science in sports · 2026Article
- Ankrd2 may alleviate denervation-induced skeletal muscle atrophy by inhibiting inflammation.Turkish journal of biology = Turk biyoloji dergisi · 2026Article
- Mechano-Signal Transduction Pathways of the Diaphragmatic Muscle and Role of Cytoskeleton.Genes · 2025Review
- Article
- Proteomic analysis of nemaline myopathy in infants reveals distinct common dysregulated proteins and cellular pathways.Frontiers in neurology · 2025Article
- ANKRD1 expression is aberrantly upregulated in the mdm mouse model of muscular dystrophy and induced by stretch through NFκB.Journal of muscle research and cell motility · 2024Article
- Targeting interleukin-1 for reversing fat browning and muscle wasting in infantile nephropathic cystinosis.Journal of cachexia, sarcopenia and muscle · 2021Article
- Article
- Muscle-specific sirtuin1 gain-of-function ameliorates skeletal muscle atrophy in a pre-clinical mouse model of cerebral ischemic stroke.FASEB bioAdvances · 2020Article
- Article
- Myonuclear accretion is a determinant of exercise-induced remodeling in skeletal muscle.eLife · 2019Article
- Ankrd2 in Mechanotransduction and Oxidative Stress Response in Skeletal Muscle: New Cues for the Pathogenesis of Muscular Laminopathies.Oxidative medicine and cellular longevity · 2019Review
- Characterization of zebrafish (Danio rerio) muscle ankyrin repeat proteins reveals their conserved response to endurance exercise.PloS one · 2018Article
- Anisotropic mechanosensitive pathways in the diaphragm and their implications in muscular dystrophies.Journal of muscle research and cell motility · 2017Review
- Characterization of muscle ankyrin repeat proteins in human skeletal muscle.American journal of physiology. Cell physiology · 2017Article
- Mechanical stretch regulates microRNA expression profile via NF-κB activation in C2C12 myoblasts.Molecular medicine reports · 2016Article
- Genome-wide Mechanosensitive MicroRNA (MechanomiR) Screen Uncovers Dysregulation of Their Regulatory Networks in the mdm Mouse Model of Muscular Dystrophy.The Journal of biological chemistry · 2015Article
- Identification of a conserved set of upregulated genes in mouse skeletal muscle hypertrophy and regrowth.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Article
- Probing muscle ankyrin-repeat protein (MARP) structure and function.Anatomical record (Hoboken, N.J. : 2007) · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The diaphragm muscles in vivo are subjected to mechanical forces both in the direction of the muscle fibers and in the direction transverse to the fibers. However, the effect of directional mechanical forces in skeletal muscle gene regulation is completely unknown. Here, we identified that stretch in the longitudinal and transverse directions to the diaphragm muscle fibers up-regulated Ankrd2 gene expression by two distinct signaling pathways in wild-type (WT) and mdm, a mouse model of muscular dystrophy with early-onset of progressive muscle-wasting. Stretch in the longitudinal direction activated both NF-kappaB and AP-1 transcription factors, whereas stretch in the transverse direction activated only AP-1 transcription factor. Interestingly, longitudinal stretch activated Ankrd2 promoter only by NF-kappaB, whereas transverse stretch activated Ankrd2 promoter by AP-1. Moreover, we found that longitudinal stretch activated Akt, which up-regulated Ankrd2 expression through NF-kappaB. However, transverse stretch activated Ras-GTP, Raf-1, and Erk1/2 proteins, which up-regulated Ankrd2 expression through AP-1. Surprisingly, the stretch-activated NF-kappaB and AP-1 signaling pathways was not involved in Ankrd2 regulation at the basal level, which was high in the mdm mouse diaphragm. Taken together, our data show the anisotropic regulation of Ankrd2 gene expression in the diaphragm muscles of WT and mdm mice via two distinct mechanosensitive signaling pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.