ArticleThe Journal of physiology2010
Acid-sensing ion channels in rat hypothalamic vasopressin neurons of the supraoptic nucleus.
Article in The Journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Olfactory receptor 78 is expressed in hypothalamic vasopressin/oxytocin neurons, parenchymal microglia and choroidal macrophages in mice.Molecular brain · 2022Article
- Lactate as an Astroglial Signal Augmenting Aerobic Glycolysis and Lipid Metabolism.Frontiers in physiology · 2021Review
- Hydrogen Sulfide Upregulates Acid-sensing Ion ChannelsFunction (Oxford, England) · 2021Article
- Acid-sensing ion channels (ASICs) influence excitability of stellate neurons in the mouse cochlear nucleus.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2019Article
- Electrophysiological properties of identified oxytocin and vasopressin neurones.Journal of neuroendocrinology · 2019Review
- Targeted Acid-Sensing Ion Channel Therapies for Migraine.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018Review
- Cellular Localization of Acid-Sensing Ion Channel 1 in Rat Nucleus Tractus Solitarii.Cellular and molecular neurobiology · 2018Article
- Effect of dietary salt intake on epithelial NaThe Journal of physiology · 2017Article
- Possible contribution of pannexin-1 to capsaicin-induced ATP release in rat nasal columnar epithelial cells.Channels (Austin, Tex.) · 2017Article
- Optogenetic approaches addressing extracellular modulation of neural excitability.Scientific reports · 2016Article
- ASICs as therapeutic targets for migraine.Neuropharmacology · 2015Review
- Acute Hypoxia Activates an ENaC-like Channel in Rat Pheochromocytoma (PC12) Cells.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2013Article
- Identification of pannexins in rat nasal mucosa.Allergy & rhinology (Providence, R.I.) · 2013Article
- The hypothalamic-neurohypophyseal system: from genome to physiology.Journal of neuroendocrinology · 2012Review
- Epithelial Na⁺ sodium channels in magnocellular cells of the rat supraoptic and paraventricular nuclei.American journal of physiology. Endocrinology and metabolism · 2012Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Body fluid balance requires the release of arginine vasopressin (AVP) from the neurohypophysis. The hypothalamic supraoptic nucleus (SON) is a major site of AVP synthesis, and AVP release is controlled somatodendritically or at the level of nerve terminals by electrical activities of magnocellular neurosecretory cells (MNCs). Acid-sensing ion channels (ASICs) are neuronal voltage-insensitive cationic channels that are activated by extracellular acidification. Although ASICs are widely expressed in the central nervous system, functional ASICs have not been assessed in AVP neurons. ASICs are modulated by lactate (La(-)), which reduces the extracellular calcium ion concentration. We hypothesize that ASICs modify neuronal function through La(-) that is generated during local hypoxia resulting from osmotic stimulation in the SON. In the present study, we used the whole-cell patch-clamp technique to show that acid-induced ASIC current is enhanced by La(-) in isolated rat SON MNCs that express an AVP-enhanced green fluorescent protein (eGFP) transgene. Immunohistochemistry and multi-cell reverse transcriptase-polymerase chain reaction experiments revealed that these neurons express the ASIC1a and ASIC2a subunits. In addition, increased La(-) production was specifically observed in the SON after osmotic stress. These results suggest that interaction between ASICs and La(-) in the SON plays an important role in the regulatory mechanism of body fluid homeostasis.
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