ArticleThe Journal of physiology2010
Mechanisms of synchronous activity in cerebellar Purkinje cells.
Article in The Journal of physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
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Who cites it
59 citing papers in PubMed, 92 citations in OpenAlex.
- Random innervation of cerebellar Purkinje cells as a substrate for diverse representational learning.bioRxiv : the preprint server for biology · 2026Article
- Behavioral correlates of Purkinje cell ensemble covariance.Nature communications · 2026Article
- Coordination of spike timing among the neurons of the cerebellum.Research square · 2026Article
- Coordination of spike timing among the neurons of the cerebellum.bioRxiv : the preprint server for biology · 2025Article
- High-speed voltage imaging of action potentials in molecular layer interneurons reveals sensory-driven synchrony that augments movement.Cell reports · 2025Article
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- Rate versus synchrony codes for cerebellar control of motor behavior.bioRxiv : the preprint server for biology · 2023Article
- Transsynaptic entrainment of cerebellar nuclear cells by alternating currents in a frequency dependent manner.Frontiers in neuroscience · 2023Article
- Impact of Purkinje Cell Simple Spike Synchrony on Signal Transmission from Flocculus.Cerebellum (London, England) · 2022Article
- The Cerebellar Cortex.Annual review of neuroscience · 2022Review
- Synchronous spiking of cerebellar Purkinje cells during control of movements.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Modulation of the dynamics of cerebellar Purkinje cells through the interaction of excitatory and inhibitory feedforward pathways.PLoS computational biology · 2021Article
- Population coding in the cerebellum: a machine learning perspective.Journal of neurophysiology · 2020Review
- Imaging Subthreshold Voltage Oscillation With Cellular Resolution in the Inferior OliveFrontiers in cellular neuroscience · 2020Article
- Current Opinions and Consensus for Studying Tremor in Animal Models.Cerebellum (London, England) · 2019Review
- Behavioral training of marmosets and electrophysiological recording from the cerebellum.Journal of neurophysiology · 2019Article
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Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Complex spike synchrony is thought to be a key feature of how inferior olive climbing fibre afferents make their vital contribution to cerebellar function. However, little is known about whether the other major cerebellar input, the mossy fibres (which generate simple spikes within Purkinje cells, PCs), exhibit a similar synchrony in impulse timing. We have used a multi-microelectrode system to record simultaneously from two or more PCs in the posterior lobe of the ketamine/xylazine-anaesthetized rat to examine the relationship between complex spike and simple spike synchrony in PC pairs located mainly in the A2 and C1 zones in crus II and the paramedian lobule. PC pairs displaying correlations in the occurrence of their complex spikes (coupled PCs) were usually located in the same zone and were also more likely to exhibit correlations in the timing of their spontaneous simple spikes and associated pauses in activity. In coupled PCs, synchrony in both complex spike and simple spike activity was enhanced and the relative timing in the occurrence of complex spikes could be altered by peripheral stimulation. We conclude that the functional coupling between PC pairs in their complex spike and simple spike activity can be significantly modified by sensory inputs, and that mechanisms besides electrotonic coupling are involved in generating PC synchrony. Synchronous activity in multiple PCs converging onto the same cerebellar nuclear cells is likely to have a significant impact on cerebellar output that could form important timing signals to orchestrate coordinated movements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.