ArticleJournal of cell science2010
Membrane wounding triggers ATP release and dysferlin-mediated intercellular calcium signaling.
Article in Journal of cell science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 53 citations in OpenAlex.
- Dysferlin promotes inflammatory macrophage responses and modulates CaLife science alliance · 2026Article
- Dysferlin and the Regulation of CaCells · 2025Review
- Spontaneous Overactivation ofInternational journal of molecular sciences · 2024Article
- Wound repair in sea urchin larvae involves pigment cells and blastocoelar cells.Developmental biology · 2022Article
- Sarcolemma wounding activates dynamin-dependent endocytosis in striated muscle.The FEBS journal · 2021Article
- Transient Cell Membrane Disruptions induce Calcium Waves in Corneal Keratocytes.Scientific reports · 2020Article
- Functional muscle hypertrophy by increased insulin-like growth factor 1 does not require dysferlin.Muscle & nerve · 2019Article
- Myoferlin, a Membrane Protein with Emerging Oncogenic Roles.BioMed research international · 2019Review
- Cellular mechanisms and signals that coordinate plasma membrane repair.Cellular and molecular life sciences : CMLS · 2018Review
- Treatment with Recombinant Human MG53 Protein Increases Membrane Integrity in a Mouse Model of Limb Girdle Muscular Dystrophy 2B.Molecular therapy : the journal of the American Society of Gene Therapy · 2017Article
- Coupling of excitation to CaThe Journal of physiology · 2017Article
- Regeneration in bipinnaria larvae of the bat star Patiria miniata induces rapid and broad new gene expression.Mechanisms of development · 2016Article
- Dysferlin-mediated phosphatidylserine sorting engages macrophages in sarcolemma repair.Nature communications · 2016Article
- POPDC1(S201F) causes muscular dystrophy and arrhythmia by affecting protein trafficking.The Journal of clinical investigation · 2016Article
- Plasma Membrane Repair: A Central Process for Maintaining Cellular Homeostasis.Physiology (Bethesda, Md.) · 2015Review
- Membrane Repair: Mechanisms and Pathophysiology.Physiological reviews · 2015Review
- Dysferlin is essential for endocytosis in the sea star oocyte.Developmental biology · 2014Article
- Alternate splicing of dysferlin C2A confers Ca²⁺-dependent and Ca²⁺-independent binding for membrane repair.Structure (London, England : 1993) · 2014Article
- Extracellular ATP activates MAPK and ROS signaling during injury response in the fungus Trichoderma atroviride.Frontiers in plant science · 2014Article
- Short-term potentiation of membrane resealing in neighboring cells is mediated by purinergic signaling.Purinergic signalling · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Dysferlin is a Ca(2+)-binding protein found in many different cell types. It is required for membrane wound repair in muscle, but it is not known whether it has the same function in other cells. Here we report the activation of an intercellular signaling pathway in sea urchin embryos by membrane wounding that evokes Ca(2+) spikes in neighboring cells. This pathway was mimicked by ATP application, and inhibited by apyrase, cadmium, and omega-agatoxin-IVA. Microinjection of dysferlin antisense phosphorodiamidate morpholino oligonucleotides blocked this pathway, whereas control morpholinos did not. Co-injection of mRNA encoding human dysferlin with the inhibitory morpholino rescued signaling activity. We conclude that in sea urchin embryos dysferlin mediates Ca(2+)-triggered intercellular signaling in response to membrane wounding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.