ArticleBiophysical journal2010
AFM imaging and analysis of electrostatic double layer forces on single DNA molecules.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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Who cites it
12 citing papers in PubMed.
- Rapid Surface Charge Mapping Based on a Liquid Crystal Microchip.Biosensors · 2024Article
- Mechanical Properties of Viruses.Sub-cellular biochemistry · 2024Review
- Article
- Locating critical events in AFM force measurements by means of one-dimensional convolutional neural networks.Scientific reports · 2022Article
- Surface charge, glycocalyx, and blood-brain barrier function.Tissue barriers · 2021Review
- Space Electroosmotic Thrusters in Ion Partitioning Soft Nanochannels.Micromachines · 2021Article
- Effect of nonionic and amphoteric surfactants on salivary pellicles reconstituted in vitro.Scientific reports · 2021Article
- Article
- Surface charge density measurement of a single protein molecule with a controlled orientation by AFM.Biophysical journal · 2021Article
- Molecular-scale visualization and surface charge density measurement of Z-DNA in aqueous solution.Scientific reports · 2019Article
- Calcium ions modulate the mechanics of tomato bushy stunt virus.Biophysical journal · 2015Article
- Mechanical stability and reversible fracture of vault particles.Biophysical journal · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Electrical double layer (EDL) forces develop between charged surfaces immersed in an electrolyte solution. Biological material surrounded by its physiological medium constitutes a case where these forces play a major role. Specifically, this work is focused on the study of the EDL force exerted by DNA molecules, a standard reference for the study of single biomolecules of nanometer size. The molecules deposited on plane substrates have been characterized by means of the atomic force microscope operated in the force spectroscopy imaging mode. Force spectroscopy imaging provides images of the topography of the DNA molecules, and of the EDL force spectrum. Due to the size of the molecule being much smaller than that of the tip, both the tip-substrate and tip-molecule interactions need to be considered in the analysis of the experimental results. We solve this problem by linearly superposing the two contributions. EDL force images are presented where DNA molecules are clearly resolved. The lateral resolution of the EDL force is discussed and compared with that of the topography. The method also allows the estimation of the DNA surface charge density, thereby obtaining reasonable values.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.