Evidence map›Paper›PMID 20441615›Full record

ReviewGenome biology2010

Between a chicken and a grape: estimating the number of human genes.

Mihaela Pertea, Steven L Salzberg

Abstract readReview
In one paragraph

Review in Genome biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. RNA variation as the driver of genomic efficiency and phenotypic complexity.International journal of biological sciences · 2026
    Review
  5. The Redesign of the Molecular Scaffold of Viral Ion Channel Blockers.Computational and structural biotechnology journal · 2026
    Article
  6. Article
  7. The state of the human coding gene catalogues.Database : the journal of biological databases and curation · 2025
    Article
  8. Article
  9. Review
  10. Article
  11. Understanding PTM Cross Talk Through a Visualization Tool, PTMViz.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Genomics in Treatment Development.Advances in neurobiology · 2023
    Article
  17. Review
  18. Article
  19. Review
  20. Molecular Biosimilarity-An AI-Driven Paradigm Shift.International journal of molecular sciences · 2022
    Review

24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Mihaela PerteaCenter for Bioinformatics and Computational Biology, University of Maryland, College Park, MD 20742, USA.
Steven L Salzberg

Funding

COMPUTATIONAL MODELING OF GENES AND GENE STRUCTURER01LM006845 · NLM · UNIV OF MARYLAND, COLLEGE PARK · PI SALZBERG, STEVEN L. · 1999 to 2010
$5.9M
Bioinformatics Software for Analyzing Microbial GenomesR01GM083873 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI SALZBERG, STEVEN L. · 2008 to 2017
$2.1M
NIGMS NIH HHS R01 GM083873NIGMS NIH HHS R01-GM083873NLM NIH HHS R01 LM006845NLM NIH HHS R01-LM006845
6 · The paper itself

Abstract

Many people expected the question 'How many genes in the human genome?' to be resolved with the publication of the genome sequence in 2001, but estimates continue to fluctuate.

Indexed as

AnimalsChickensGenesGenome, HumanHumansTranscription, GeneticVitis

Identifiers

PMID20441615
PMCPMC2898077

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.